TY  - JOUR
AU  - Quattrone, Andrea
AU  - Franzmeier, Nicolai
AU  - Levin, Johannes
AU  - Petzold, Gabor C
AU  - Spottke, Annika
AU  - Brosseron, Frederic
AU  - Falkenburger, Björn
AU  - Prudlo, Johannes
AU  - Gasser, Thomas
AU  - Höglinger, Günter U
TI  - Prospective Multicenter Evaluation of the MDS 'Suggestive of PSP' Diagnostic Criteria.
JO  - Movement disorders
VL  - 40
IS  - 3
SN  - 0885-3185
CY  - New York, NY
PB  - Wiley
M1  - DZNE-2025-00448
SP  - 526 - 536
PY  - 2025
AB  - The recent Movement Disorders Society (MDS)-progressive supranuclear palsy (PSP) diagnostic criteria conceptualized three clinical diagnostic certainty levels: 'suggestive of PSP' for sensitive early diagnosis based on subtle clinical signs, 'possible PSP' balancing sensitivity and specificity, and 'probable PSP' highly specific for PSP pathology.The aim of this study was to prospectively validate the criteria against long-term clinical follow-up and characterize the diagnostic certainty increase over time.Patients with 'possible PSP' or 'suggestive of PSP' diagnosis and clinical follow-up were recruited in two German multicenter longitudinal observational studies (ProPSP and DescribePSP). The cumulative percentage of patients longitudinally increasing diagnostic certainty was assessed over up to 2.5 years of follow-up. The sample size per arm required to detect 30
KW  - Humans
KW  - Supranuclear Palsy, Progressive: diagnosis
KW  - Female
KW  - Male
KW  - Aged
KW  - Middle Aged
KW  - Longitudinal Studies
KW  - Prospective Studies
KW  - Sensitivity and Specificity
KW  - Aged, 80 and over
KW  - diagnostic criteria (Other)
KW  - longitudinal (Other)
KW  - progressive supranuclear palsy (Other)
KW  - suggestive of PSP (Other)
KW  - validation (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:39797511
C2  - pmc:PMC11926504
DO  - DOI:10.1002/mds.30112
UR  - https://pub.dzne.de/record/277727
ER  -