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@ARTICLE{Quattrone:277727,
      author       = {Quattrone, Andrea and Franzmeier, Nicolai and Levin,
                      Johannes and Petzold, Gabor C and Spottke, Annika and
                      Brosseron, Frederic and Falkenburger, Björn and Prudlo,
                      Johannes and Gasser, Thomas and Höglinger, Günter U},
      collaboration = {DESCRIBE-PSP Group, The ProPSP Group},
      othercontributors = {Petzold, Gabor C and Kimmich, Okka and Falkenburger, Björn
                          and Dinter, Elisabeth and Höglinger, Günter and Palleis,
                          Carla and Bernhardt, Alexander Maximilian and Levin,
                          Johannes and Katzdobler, Sabrina and Jäck, Alexander and
                          Prudlo, Johannes and Gasser, Thomas and Brockmann, Kathrin
                          and Spottke, Annika and Gamez, Anna and Brosseron, Frederic
                          and Klietz, Martin and Wegner, Florian and Pötter-Nerger,
                          Monika and Pedrosa, David J and Eggers, Carsten and
                          Mollenhauer, Brit and Claus, Inga and Regensburger, Martin
                          and Süß, Patrick and Warnecke, Tobias and Gandor, Florin
                          and Gruber, Doreen and Berg, Daniela and Paschen, Steffen
                          and Claßen, Joseph and Kassubek, Jan and Jost, Wolfgang H
                          and Tönges, Lars},
      title        = {{P}rospective {M}ulticenter {E}valuation of the {MDS}
                      '{S}uggestive of {PSP}' {D}iagnostic {C}riteria.},
      journal      = {Movement disorders},
      volume       = {40},
      number       = {3},
      issn         = {0885-3185},
      address      = {New York, NY},
      publisher    = {Wiley},
      reportid     = {DZNE-2025-00448},
      pages        = {526 - 536},
      year         = {2025},
      abstract     = {The recent Movement Disorders Society (MDS)-progressive
                      supranuclear palsy (PSP) diagnostic criteria conceptualized
                      three clinical diagnostic certainty levels: 'suggestive of
                      PSP' for sensitive early diagnosis based on subtle clinical
                      signs, 'possible PSP' balancing sensitivity and specificity,
                      and 'probable PSP' highly specific for PSP pathology.The aim
                      of this study was to prospectively validate the criteria
                      against long-term clinical follow-up and characterize the
                      diagnostic certainty increase over time.Patients with
                      'possible PSP' or 'suggestive of PSP' diagnosis and clinical
                      follow-up were recruited in two German multicenter
                      longitudinal observational studies (ProPSP and DescribePSP).
                      The cumulative percentage of patients longitudinally
                      increasing diagnostic certainty was assessed over up to 2.5
                      years of follow-up. The sample size per arm required to
                      detect $30\%$ attenuated rate in diagnostic certainty
                      increase in trials was estimated over multiple time
                      intervals.Of 254 patients with available longitudinal data,
                      61 patients had low diagnostic certainty at baseline (48
                      suggestive of PSP, 13 possible PSP) and multiple clinical
                      visits (median: 3, range: 2-4). The cumulative percentage of
                      patients increasing diagnostic certainty progressed with
                      follow-up duration $(30.4\%$ at 6 months, $51.7\%$ at 1
                      year, $80.4\%$ at 2.5 years). The sample size required to
                      detect $30\%$ reduction in diagnostic certainty increase
                      rate within 1 year was 163, slightly smaller than that
                      required using the PSP rating scale.Most 'suggestive of PSP'
                      patients increased diagnostic certainty upon longitudinal
                      follow-up, providing the first prospective multicenter
                      validation of MDS-PSP diagnostic criteria. Our data support
                      the design of trials tailored for these early-stage
                      patients, suggesting the PSP rating scale and the diagnostic
                      certainty increase rate as potential endpoint measures. ©
                      2025 The Author(s). Movement Disorders published by Wiley
                      Periodicals LLC on behalf of International Parkinson and
                      Movement Disorder Society.},
      keywords     = {Humans / Supranuclear Palsy, Progressive: diagnosis /
                      Female / Male / Aged / Middle Aged / Longitudinal Studies /
                      Prospective Studies / Sensitivity and Specificity / Aged, 80
                      and over / diagnostic criteria (Other) / longitudinal
                      (Other) / progressive supranuclear palsy (Other) /
                      suggestive of PSP (Other) / validation (Other)},
      cin          = {Clinical Research (Munich) / AG Levin / AG Petzold / AG
                      Spottke / AG Heneka / AG Falkenburger / AG Teipel / AG
                      Gasser},
      ddc          = {610},
      cid          = {I:(DE-2719)1111015 / I:(DE-2719)1111016 /
                      I:(DE-2719)1013020 / I:(DE-2719)1011103 / I:(DE-2719)1011303
                      / I:(DE-2719)1710012 / I:(DE-2719)1510100 /
                      I:(DE-2719)1210000},
      pnm          = {353 - Clinical and Health Care Research (POF4-353)},
      pid          = {G:(DE-HGF)POF4-353},
      experiment   = {EXP:(DE-2719)DESCRIBE-PSP-20160101},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:39797511},
      pmc          = {pmc:PMC11926504},
      doi          = {10.1002/mds.30112},
      url          = {https://pub.dzne.de/record/277727},
}