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000277728 1001_ $$0P:(DE-2719)9003374$$aMangiarotti, Agustin$$b0$$eFirst author$$udzne
000277728 245__ $$aLipid packing and cholesterol content regulate membrane wetting and remodeling by biomolecular condensates.
000277728 260__ $$a[London]$$bSpringer Nature$$c2025
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000277728 520__ $$aBiomolecular condensates play a central role in cellular processes by interacting with membranes driving wetting transitions and inducing mutual remodeling. While condensates are known to locally alter membrane properties such as lipid packing and hydration, it remains unclear how membrane composition and phase state in turn affect condensate affinity. Here, we show that it is not only the membrane phase itself, but rather the degree of lipid packing that determines the condensate affinity for membranes. Increasing lipid chain length, saturation, or cholesterol content, enhances lipid packing, thereby decreasing condensate interaction. This regulatory mechanism is consistent across various condensate-membrane systems, highlighting the critical role of the membrane interface. In addition, protein adsorption promotes extensive membrane remodeling, including the formation of tubes and double-membrane sheets. Our findings reveal a mechanism by which membrane composition fine-tunes condensate wetting, highlighting its potential impact on cellular functions and organelle interactions.
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000277728 650_7 $$097C5T2UQ7J$$2NLM Chemicals$$aCholesterol
000277728 650_7 $$2NLM Chemicals$$aMembrane Lipids
000277728 650_7 $$2NLM Chemicals$$aLipid Bilayers
000277728 650_7 $$2NLM Chemicals$$aLipids
000277728 650_2 $$2MeSH$$aCholesterol: metabolism
000277728 650_2 $$2MeSH$$aCholesterol: chemistry
000277728 650_2 $$2MeSH$$aWettability
000277728 650_2 $$2MeSH$$aBiomolecular Condensates: metabolism
000277728 650_2 $$2MeSH$$aBiomolecular Condensates: chemistry
000277728 650_2 $$2MeSH$$aCell Membrane: metabolism
000277728 650_2 $$2MeSH$$aMembrane Lipids: metabolism
000277728 650_2 $$2MeSH$$aMembrane Lipids: chemistry
000277728 650_2 $$2MeSH$$aLipid Bilayers: metabolism
000277728 650_2 $$2MeSH$$aLipid Bilayers: chemistry
000277728 650_2 $$2MeSH$$aLipids: chemistry
000277728 650_2 $$2MeSH$$aAdsorption
000277728 7001_ $$aSabri, Elias$$b1
000277728 7001_ $$aSchmidt, Kita Valerie$$b2
000277728 7001_ $$0P:(DE-2719)9000582$$aHoffmann, Christian$$b3
000277728 7001_ $$0P:(DE-2719)9000670$$aMilovanovic, Dragomir$$b4
000277728 7001_ $$aLipowsky, Reinhard$$b5
000277728 7001_ $$00000-0002-3872-8502$$aDimova, Rumiana$$b6
000277728 773__ $$0PERI:(DE-600)2553671-0$$a10.1038/s41467-025-57985-2$$gVol. 16, no. 1, p. 2756$$n1$$p2756$$tNature Communications$$v16$$x2041-1723$$y2025
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