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@ARTICLE{Mangiarotti:277728,
      author       = {Mangiarotti, Agustin and Sabri, Elias and Schmidt, Kita
                      Valerie and Hoffmann, Christian and Milovanovic, Dragomir
                      and Lipowsky, Reinhard and Dimova, Rumiana},
      title        = {{L}ipid packing and cholesterol content regulate membrane
                      wetting and remodeling by biomolecular condensates.},
      journal      = {Nature Communications},
      volume       = {16},
      number       = {1},
      issn         = {2041-1723},
      address      = {[London]},
      publisher    = {Springer Nature},
      reportid     = {DZNE-2025-00449},
      pages        = {2756},
      year         = {2025},
      abstract     = {Biomolecular condensates play a central role in cellular
                      processes by interacting with membranes driving wetting
                      transitions and inducing mutual remodeling. While
                      condensates are known to locally alter membrane properties
                      such as lipid packing and hydration, it remains unclear how
                      membrane composition and phase state in turn affect
                      condensate affinity. Here, we show that it is not only the
                      membrane phase itself, but rather the degree of lipid
                      packing that determines the condensate affinity for
                      membranes. Increasing lipid chain length, saturation, or
                      cholesterol content, enhances lipid packing, thereby
                      decreasing condensate interaction. This regulatory mechanism
                      is consistent across various condensate-membrane systems,
                      highlighting the critical role of the membrane interface. In
                      addition, protein adsorption promotes extensive membrane
                      remodeling, including the formation of tubes and
                      double-membrane sheets. Our findings reveal a mechanism by
                      which membrane composition fine-tunes condensate wetting,
                      highlighting its potential impact on cellular functions and
                      organelle interactions.},
      keywords     = {Cholesterol: metabolism / Cholesterol: chemistry /
                      Wettability / Biomolecular Condensates: metabolism /
                      Biomolecular Condensates: chemistry / Cell Membrane:
                      metabolism / Membrane Lipids: metabolism / Membrane Lipids:
                      chemistry / Lipid Bilayers: metabolism / Lipid Bilayers:
                      chemistry / Lipids: chemistry / Adsorption / Cholesterol
                      (NLM Chemicals) / Membrane Lipids (NLM Chemicals) / Lipid
                      Bilayers (NLM Chemicals) / Lipids (NLM Chemicals)},
      cin          = {AG Milovanovic (Berlin) / AG Milovanovic (Bonn)},
      ddc          = {500},
      cid          = {I:(DE-2719)1813002 / I:(DE-2719)1013043},
      pnm          = {351 - Brain Function (POF4-351)},
      pid          = {G:(DE-HGF)POF4-351},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:40113768},
      pmc          = {pmc:PMC11926106},
      doi          = {10.1038/s41467-025-57985-2},
      url          = {https://pub.dzne.de/record/277728},
}