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| Home > Publications Database > The LRRK2 p.L1795F variant causes Parkinson's disease in the European population. > print |
| Home > Publications Database > The LRRK2 p.L1795F variant causes Parkinson's disease in the European population. > print |
| 001 | 277789 | ||
| 005 | 20250427001124.0 | ||
| 024 | 7 | _ | |a 10.1038/s41531-025-00896-2 |2 doi |
| 024 | 7 | _ | |a pmid:40133296 |2 pmid |
| 024 | 7 | _ | |a altmetric:175474721 |2 altmetric |
| 037 | _ | _ | |a DZNE-2025-00467 |
| 041 | _ | _ | |a English |
| 082 | _ | _ | |a 610 |
| 100 | 1 | _ | |a Lange, Lara M |0 P:(DE-2719)9002038 |b 0 |
| 245 | _ | _ | |a The LRRK2 p.L1795F variant causes Parkinson's disease in the European population. |
| 260 | _ | _ | |a [London] |c 2025 |b Springer Nature |
| 336 | 7 | _ | |a article |2 DRIVER |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1743170398_12530 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
| 336 | 7 | _ | |a JOURNAL_ARTICLE |2 ORCID |
| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 520 | _ | _ | |a LRRK2-PD represents the most common form of autosomal dominant Parkinson's disease. We identified the LRRK2 p.L1795F variant in three families and six additional unrelated cases using genetic data from over 50,000 individuals. Carriers with available genotyping data shared a common haplotype. The clinical presentation resembles other LRRK2-PD forms. Combined with published functional evidence showing strongly enhanced LRRK2 kinase activity, we provide evidence that LRRK2 p.L1795F is pathogenic. |
| 536 | _ | _ | |a 354 - Disease Prevention and Healthy Aging (POF4-354) |0 G:(DE-HGF)POF4-354 |c POF4-354 |f POF IV |x 0 |
| 588 | _ | _ | |a Dataset connected to CrossRef, PubMed, , Journals: pub.dzne.de |
| 700 | 1 | _ | |a Levine, Kristin |0 0000-0002-5702-0980 |b 1 |
| 700 | 1 | _ | |a Fox, Susan H |b 2 |
| 700 | 1 | _ | |a Marras, Connie |b 3 |
| 700 | 1 | _ | |a Ahmed, Nazish |b 4 |
| 700 | 1 | _ | |a Kuznetsov, Nicole |b 5 |
| 700 | 1 | _ | |a Vitale, Dan |b 6 |
| 700 | 1 | _ | |a Iwaki, Hirotaka |0 0000-0002-8982-7885 |b 7 |
| 700 | 1 | _ | |a Lohmann, Katja |0 P:(DE-2719)9000191 |b 8 |
| 700 | 1 | _ | |a Marsili, Luca |0 0000-0002-6438-9911 |b 9 |
| 700 | 1 | _ | |a Espay, Alberto J |0 0000-0002-3389-136X |b 10 |
| 700 | 1 | _ | |a Bauer, Peter |b 11 |
| 700 | 1 | _ | |a Beetz, Christian |b 12 |
| 700 | 1 | _ | |a Martin, Jessica |0 0009-0000-0830-9289 |b 13 |
| 700 | 1 | _ | |a Factor, Stewart A |0 0000-0002-0449-973X |b 14 |
| 700 | 1 | _ | |a Higginbotham, Lenora A |b 15 |
| 700 | 1 | _ | |a Chen, Honglei |b 16 |
| 700 | 1 | _ | |a Leonard, Hampton |b 17 |
| 700 | 1 | _ | |a Nalls, Mike A |0 0000-0003-0319-4325 |b 18 |
| 700 | 1 | _ | |a Mencacci, Niccolo E |b 19 |
| 700 | 1 | _ | |a Morris, Huw R |0 0000-0002-5473-3774 |b 20 |
| 700 | 1 | _ | |a Singleton, Andrew B |b 21 |
| 700 | 1 | _ | |a Klein, Christine |b 22 |
| 700 | 1 | _ | |a Blauwendraat, Cornelis |0 P:(DE-2719)2810837 |b 23 |
| 700 | 1 | _ | |a Fang, Zih-Hua |0 P:(DE-2719)9001362 |b 24 |e Last author |
| 700 | 1 | _ | |a Program, Global Parkinson’s Genetics |b 25 |e Collaboration Author |
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| 773 | _ | _ | |a 10.1038/s41531-025-00896-2 |g Vol. 11, no. 1, p. 58 |0 PERI:(DE-600)2819218-7 |n 1 |p 58 |t npj Parkinson's Disease |v 11 |y 2025 |x 2373-8057 |
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