% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{Pfaff:277790,
      author       = {Pfaff, Michelle and Hoffmann, Wolfgang and Boekholt,
                      Melanie and Biernetzky, Olga and Blotenberg, Iris and Afrin,
                      Dilshad and Platen, Moritz and Teipel, Stefan and Thyrian,
                      Jochen René and Kilimann, Ingo and Michalowsky, Bernhard},
      title        = {{C}ost-{E}ffectiveness of a {D}igitally {S}upported {C}are
                      {M}anagement {P}rogram for {C}aregivers of {P}eople {W}ith
                      {D}ementia.},
      journal      = {Value in health},
      volume       = {28},
      number       = {4},
      issn         = {1098-3015},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier},
      reportid     = {DZNE-2025-00468},
      pages        = {527 - 535},
      year         = {2025},
      abstract     = {To examine the cost-effectiveness of a digitally supported
                      care management system (CMS) for caregivers of people with
                      dementia (PwD) compared with usual care.The analysis was
                      based on 192 caregivers (n = 96 CMS, n = 96 usual care) of
                      PwD in a cluster-randomized controlled trial testing a
                      digitally supported CMS, aiming to identify and address
                      caregivers' unmet needs and develop and implement an
                      individualized support and care plan over 6 months.
                      Incremental costs from the public-payer and societal
                      perspectives, quality-adjusted life years (QALY), and the
                      incremental cost-effectiveness ratio 6 months after baseline
                      were calculated using multivariate regression models. We
                      assessed the probability of cost-effectiveness using a range
                      of willingness-to-pay thresholds.Caregivers in the
                      intervention group gained QALYs (+0.004 $[95\%$ CI -0.003 to
                      0.012], P value = .225) and had lower costs from the public
                      payer (-378€ [1926-1168], P value = .630), but higher
                      costs from the societal perspective (+1324 [-3634 to 6284],
                      P value = .599). The intervention dominated usual care from
                      the payer perspective, whereas the incremental
                      cost-effectiveness ratio was €331 000/QALY from a societal
                      perspective. The probability of cost-effectiveness was
                      $72\%$ and $79\%$ from the public payer and $33\%$ and
                      $35\%$ from a societal perspective at the willingness-to-pay
                      thresholds threshold of €40 000 and €80 000/QALY
                      gained.CMS was likely cost-effective from the payer but not
                      from a societal perspective, underlining the importance of
                      informal care. The gain in QALY was marginal and could be
                      due to the short observation period. Focusing on both the
                      caregiver and the PwD, rather than assessing the PwD needs
                      through the caregiver, could improve the cost-effectiveness
                      results.},
      keywords     = {Humans / Cost-Benefit Analysis / Caregivers: economics /
                      Dementia: economics / Dementia: therapy / Male / Female /
                      Quality-Adjusted Life Years / Aged / Middle Aged / Aged, 80
                      and over / Health Care Costs / caregiver support (Other) /
                      collaborative care (Other) / cost-effectiveness (Other) /
                      dementia (Other) / informal care (Other)},
      cin          = {AG Michalowsky / AG Hoffmann / AG Teipel / AG Thyrian},
      ddc          = {610},
      cid          = {I:(DE-2719)5000067 / I:(DE-2719)1510600 /
                      I:(DE-2719)1510100 / I:(DE-2719)1510800},
      pnm          = {353 - Clinical and Health Care Research (POF4-353)},
      pid          = {G:(DE-HGF)POF4-353},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:39922302},
      doi          = {10.1016/j.jval.2025.01.011},
      url          = {https://pub.dzne.de/record/277790},
}