TY  - JOUR
AU  - Fink, Anne
AU  - Pavlou, Maria Angeliki S
AU  - Roomp, Kirsten
AU  - Schneider, Jochen G
TI  - Declining trends in the incidence of Parkinson's disease: A cohort study in Germany.
JO  - Journal of Parkinson's Disease
VL  - 15
IS  - 1
SN  - 1877-7171
CY  - Amsterdam
PB  - IOS Press
M1  - DZNE-2025-00469
SP  - 1877718X241306132
PY  - 2025
AB  - BackgroundEpidemiologic evidence from different countries shows both increasing and decreasing incidence rates of Parkinson's disease over time without clear trends.ObjectiveWe aimed to investigate age-specific incidence rates of Parkinson's disease and possible explanations for the observed trends in Germany over a 10-year period.MethodsTwo different random samples of subjects aged ≥50 years included in 2004-2009 and 2014-2019, each consisting of 250,000 individuals, were drawn from Germany's largest health care insurance company followed up for new Parkinson's disease cases. We compared the age-specific incidence rates of Parkinson's disease for both cohorts and performed Cox regression models to calculate the hazard ratios (HR) of PD in the second period compared with the first period, adjusted for age, sex, and risk factors for Parkinson's disease.ResultsFor most age groups in men and in women, we found lower age-specific Parkinson's disease incidence rates in the second period. Cox regression analysis showed an overall 18
KW  - Humans
KW  - Parkinson Disease: epidemiology
KW  - Germany: epidemiology
KW  - Male
KW  - Female
KW  - Incidence
KW  - Middle Aged
KW  - Aged
KW  - Cohort Studies
KW  - Aged, 80 and over
KW  - Risk Factors
KW  - Proportional Hazards Models
KW  - Age Factors
KW  - cohort study (Other)
KW  - epidemiology (Other)
KW  - parkinson's disease (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:39973480
DO  - DOI:10.1177/1877718X241306132
UR  - https://pub.dzne.de/record/277791
ER  -