TY  - JOUR
AU  - Mathiopoulou, Varvara
AU  - Habets, Jeroen
AU  - Feldmann, Lucia K
AU  - Busch, Johannes L
AU  - Roediger, Jan
AU  - Behnke, Jennifer K
AU  - Schneider, Gerd-Helge
AU  - Faust, Katharina
AU  - Kühn, Andrea
TI  - Gamma entrainment induced by deep brain stimulation as a biomarker for motor improvement with neuromodulation.
JO  - Nature Communications
VL  - 16
IS  - 1
SN  - 2041-1723
CY  - [London]
PB  - Springer Nature
M1  - DZNE-2025-00473
SP  - 2956
PY  - 2025
AB  - Finely tuned gamma (FTG) oscillations from the subthalamic nucleus (STN) and cortex in Parkinson's disease (PD) patients undergoing deep brain stimulation (DBS) are often associated with dyskinesia. Recently it was shown that DBS entrains gamma activity at 1:2 of the stimulation frequency; however, the functional role of this signal is not yet fully understood. We recorded local field potentials from the STN in 19 chronically implanted PD patients on dopaminergic medication during DBS, at rest, and during repetitive movements. Here we show that high-frequency DBS induced 1:2 gamma entrainment in 15/19 patients. Spontaneous FTG was present in 8 patients; in five of these patients dyskinesia occurred or were enhanced with entrained gamma activity during stimulation. Further, there was a significant increase in the power of 1:2 entrained gamma activity during movement in comparison to rest, while patients with entrainment had faster movements compared to those without. These findings argue for a functional relevance of the stimulation-induced 1:2 gamma entrainment in PD patients as a prokinetic activity that, however, is not necessarily promoting dyskinesia. DBS-induced entrainment can be a promising neurophysiological biomarker for identifying the optimal amplitude during closed-loop DBS.
KW  - Humans
KW  - Deep Brain Stimulation: methods
KW  - Parkinson Disease: therapy
KW  - Parkinson Disease: physiopathology
KW  - Subthalamic Nucleus: physiopathology
KW  - Male
KW  - Female
KW  - Middle Aged
KW  - Aged
KW  - Gamma Rhythm: physiology
KW  - Biomarkers
KW  - Dyskinesias: physiopathology
KW  - Dyskinesias: therapy
KW  - Dyskinesias: etiology
KW  - Biomarkers (NLM Chemicals)
LB  - PUB:(DE-HGF)16
C6  - pmid:40140380
DO  - DOI:10.1038/s41467-025-58132-7
UR  - https://pub.dzne.de/record/277795
ER  -