%0 Journal Article
%A Kunze, L. H.
%A Palumbo, G.
%A Gnörich, J.
%A Wind, Karin
%A Schaefer, R.
%A Lindner, S.
%A Gildehaus, F-J
%A Ziegler, S.
%A Brendel, Matthias
%T Fibrillar amyloidosis and synaptic vesicle protein expression progress jointly in the cortex of a mouse model with β-amyloid pathology.
%J NeuroImage
%V 310
%@ 1053-8119
%C Orlando, Fla.
%I Academic Press
%M DZNE-2025-00485
%P 121165
%D 2025
%X Neurodegeneration, accumulation of β-amyloid (Aβ) plaques, and neuroinflammation are the major hallmarks of Alzheimer's disease. Here, we aimed to investigate the temporal and spatial association between synaptic activity, Aβ plaque load, and neuroinflammation in an Aβ mouse model with limited neurodegeneration. 26 APPSL70 and 15 C57Bl/6 mice underwent longitudinal PET-scans with [18F]UCB-H from plaque onset to levels of strong plaque load (5.3 - 11.0 months of age) to assess the synaptic vesicle protein 2A (SV2A) expression, [18F]FBB to determine the fibrillar Aβ plaque load, and [18F]GE-180 and [18F]F-DED to assess microglial and astroglial (re)activity. Statistical parametric mapping was performed to uncover similarities between the binding patterns of all four tracers. We found a continuous increase in Aβ-PET in APPSL70 mice from 5.3 to 11.0 months of age, resulting in a significantly higher [18F]FBB PET signal in the cortex, hippocampus, and thalamus of APPSL70 mice compared to C57Bl/6 mice at 11.0 months of age. Parallel increases in SV2A-PET signals were observed in the cortex and thalamus of APPSL70 mice compared to C57Bl/6 mice. Statistical parametric mapping revealed a similar pattern of Aβ- and SV2A-PET differences (dice coefficient 53 
%K Alzheimer's disease (Other)
%K SV2A-PET (Other)
%K Synaptic density (Other)
%K β-amyloid (Other)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:40120783
%R 10.1016/j.neuroimage.2025.121165
%U https://pub.dzne.de/record/277813