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@ARTICLE{Kunze:277813,
      author       = {Kunze, L. H. and Palumbo, G. and Gnörich, J. and Wind,
                      Karin and Schaefer, R. and Lindner, S. and Gildehaus, F-J
                      and Ziegler, S. and Brendel, Matthias},
      title        = {{F}ibrillar amyloidosis and synaptic vesicle protein
                      expression progress jointly in the cortex of a mouse model
                      with β-amyloid pathology.},
      journal      = {NeuroImage},
      volume       = {310},
      issn         = {1053-8119},
      address      = {Orlando, Fla.},
      publisher    = {Academic Press},
      reportid     = {DZNE-2025-00485},
      pages        = {121165},
      year         = {2025},
      abstract     = {Neurodegeneration, accumulation of β-amyloid (Aβ)
                      plaques, and neuroinflammation are the major hallmarks of
                      Alzheimer's disease. Here, we aimed to investigate the
                      temporal and spatial association between synaptic activity,
                      Aβ plaque load, and neuroinflammation in an Aβ mouse model
                      with limited neurodegeneration. 26 APPSL70 and 15 C57Bl/6
                      mice underwent longitudinal PET-scans with [18F]UCB-H from
                      plaque onset to levels of strong plaque load (5.3 - 11.0
                      months of age) to assess the synaptic vesicle protein 2A
                      (SV2A) expression, [18F]FBB to determine the fibrillar Aβ
                      plaque load, and [18F]GE-180 and [18F]F-DED to assess
                      microglial and astroglial (re)activity. Statistical
                      parametric mapping was performed to uncover similarities
                      between the binding patterns of all four tracers. We found a
                      continuous increase in Aβ-PET in APPSL70 mice from 5.3 to
                      11.0 months of age, resulting in a significantly higher
                      [18F]FBB PET signal in the cortex, hippocampus, and thalamus
                      of APPSL70 mice compared to C57Bl/6 mice at 11.0 months of
                      age. Parallel increases in SV2A-PET signals were observed in
                      the cortex and thalamus of APPSL70 mice compared to C57Bl/6
                      mice. Statistical parametric mapping revealed a similar
                      pattern of Aβ- and SV2A-PET differences (dice coefficient
                      53 $\%).$ Patterns of microglia activation showed stronger
                      congruency with SV2A expression (dice coefficient 58 $\%)$
                      than patterns of reactive astrogliosis (dice coefficient 26
                      $\%).$ APPSL70 mice with limited neurodegeneration comprise
                      a close temporal and spatial association between SV2A
                      expression, Aβ plaque load, and microglial activation. SV2A
                      PET imaging in APPSL70 mice may facilitate longitudinal
                      monitoring of increased synaptic activity in the earliest
                      phase of AD.},
      keywords     = {Alzheimer's disease (Other) / SV2A-PET (Other) / Synaptic
                      density (Other) / β-amyloid (Other)},
      cin          = {AG Haass / AG Herms},
      ddc          = {610},
      cid          = {I:(DE-2719)1110007 / I:(DE-2719)1110001},
      pnm          = {352 - Disease Mechanisms (POF4-352)},
      pid          = {G:(DE-HGF)POF4-352},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:40120783},
      doi          = {10.1016/j.neuroimage.2025.121165},
      url          = {https://pub.dzne.de/record/277813},
}