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@ARTICLE{Vinopal:277814,
      author       = {Vinopal, Stanislav and Bradke, Frank},
      title        = {{C}entrosomal and acentrosomal microtubule nucleation
                      during neuronal development},
      journal      = {Current opinion in neurobiology},
      volume       = {92},
      issn         = {0959-4388},
      address      = {Philadelphia, Pa.},
      publisher    = {Current Biology},
      reportid     = {DZNE-2025-00486},
      pages        = {103016},
      year         = {2025},
      abstract     = {Neurons rely on the microtubule cytoskeleton to create and
                      maintain their sophisticated cellular architectures.
                      Advances in cryogenic electron microscopy, expansion
                      microscopy, live imaging, and gene editing have enabled
                      novel insights into mechanisms of centrosomal and
                      acentrosomal microtubule nucleation, the key process
                      generating new microtubules. This has paved the way for the
                      functional dissection of distinct microtubule networks that
                      regulate various processes during neuronal development,
                      including neuronal delamination, polarization, migration,
                      maturation, and synapse function. We review recent progress
                      in understanding the molecular concepts of microtubule
                      nucleation, how these concepts underlie neurodevelopmental
                      processes, and pinpoint the open questions. Since
                      microtubules play a pivotal role in axon regeneration within
                      the adult central nervous system, understanding the
                      processes of microtubule nucleation could inform strategies
                      to enhance the regenerative capabilities of neurons in the
                      future.},
      subtyp        = {Review Article},
      cin          = {AG Bradke},
      ddc          = {610},
      cid          = {I:(DE-2719)1013002},
      pnm          = {351 - Brain Function (POF4-351)},
      pid          = {G:(DE-HGF)POF4-351},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:40147111},
      doi          = {10.1016/j.conb.2025.103016},
      url          = {https://pub.dzne.de/record/277814},
}