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000277882 1001_ $$00009-0001-1436-1232$$aNchioua, Rayhane$$b0
000277882 245__ $$aHost ZAP activity correlates with the levels of CpG suppression in primate lentiviruses.
000277882 260__ $$aWashington, DC$$bNational Acad. of Sciences$$c2025
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000277882 520__ $$aZinc-finger antiviral protein (ZAP) is thought to drive the suppression of CpG dinucleotides in many viruses to mimic the composition of their host genomes. However, in vivo evidence is sparse. Here, we investigated the reasons for unusually high CpG levels in SIVmus and SIVmon from mustached and mona monkeys, descendants of one of the precursors of HIV-1. We show that SIVmus is not resistant to ZAP inhibition. Instead, these Cercopithecus monkey hosts differ from other primate species by a splice site mutation and express the poorly active extralarge XL rather than the highly active L isoform of ZAP. Similarly, higher CpG levels in endogenous prosimian lentiviruses were associated with low activity of the corresponding host lemur ZAPs. In addition, lemur genes also show lower CpG suppression than other primates. Thus, the antiviral activity of ZAP not only affects suppression of CpG dinucleotides in viral transcripts but possibly also host genomes.
000277882 536__ $$0G:(DE-HGF)POF4-351$$a351 - Brain Function (POF4-351)$$cPOF4-351$$fPOF IV$$x0
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000277882 650_7 $$2Other$$aCpG suppression
000277882 650_7 $$2Other$$aprimate lentiviruses
000277882 650_7 $$2Other$$avirus-host arms race
000277882 650_7 $$2Other$$azinc-finger antiviral protein
000277882 650_7 $$2NLM Chemicals$$aDinucleoside Phosphates
000277882 650_7 $$2NLM Chemicals$$aRNA-Binding Proteins
000277882 650_7 $$02382-65-2$$2NLM Chemicals$$acytidylyl-3'-5'-guanosine
000277882 650_7 $$2NLM Chemicals$$aZC3HAV1 protein, human
000277882 650_2 $$2MeSH$$aAnimals
000277882 650_2 $$2MeSH$$aHumans
000277882 650_2 $$2MeSH$$aDinucleoside Phosphates: metabolism
000277882 650_2 $$2MeSH$$aDinucleoside Phosphates: genetics
000277882 650_2 $$2MeSH$$aLentiviruses, Primate: genetics
000277882 650_2 $$2MeSH$$aLentiviruses, Primate: metabolism
000277882 650_2 $$2MeSH$$aRNA-Binding Proteins: metabolism
000277882 650_2 $$2MeSH$$aRNA-Binding Proteins: genetics
000277882 650_2 $$2MeSH$$aSimian Immunodeficiency Virus: genetics
000277882 650_2 $$2MeSH$$aCpG Islands: genetics
000277882 650_2 $$2MeSH$$aHIV-1: genetics
000277882 7001_ $$00000-0001-7302-6015$$aKmiec, Dorota$$b1
000277882 7001_ $$00000-0001-9192-5866$$aKrchlikova, Veronika$$b2
000277882 7001_ $$aMattes, Sarah$$b3
000277882 7001_ $$00000-0003-0059-5289$$aNoettger, Sabrina$$b4
000277882 7001_ $$aBibollet-Ruche, Frederic$$b5
000277882 7001_ $$00000-0003-1484-4207$$aRussell, Ronnie M$$b6
000277882 7001_ $$0P:(DE-2719)9003481$$aSparrer, Konstantin M J$$b7
000277882 7001_ $$00000-0002-7487-6051$$aCharpentier, Thomas$$b8
000277882 7001_ $$aTardy, Frédéric$$b9
000277882 7001_ $$00000-0002-2116-5061$$aBosinger, Steven E$$b10
000277882 7001_ $$00000-0001-7665-0040$$aSauter, Daniel$$b11
000277882 7001_ $$00000-0002-9400-9887$$aHahn, Beatrice H$$b12
000277882 7001_ $$00000-0002-7052-2360$$aKirchhoff, Frank$$b13
000277882 773__ $$0PERI:(DE-600)1461794-8$$a10.1073/pnas.2419489122$$gVol. 122, no. 15, p. e2419489122$$n15$$pe2419489122$$tProceedings of the National Academy of Sciences of the United States of America$$v122$$x0027-8424$$y2025
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