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@ARTICLE{Bedarf:277883,
      author       = {Bedarf, Janis and Romano, Stefano and Heinzmann, Silke
                      Sophie and Duncan, Anthony and Traka, Maria H and Ng, Duncan
                      and Segovia-Lizano, Daniella and Simon, Marie-Christine and
                      Narbad, Arjan and Wüllner, Ullrich and Hildebrand, Falk},
      title        = {{A} prebiotic dietary pilot intervention restores faecal
                      metabolites and may be neuroprotective in {P}arkinson's
                      {D}isease.},
      journal      = {npj Parkinson's Disease},
      volume       = {11},
      number       = {1},
      issn         = {2373-8057},
      address      = {[London]},
      publisher    = {Springer Nature},
      reportid     = {DZNE-2025-00503},
      pages        = {66},
      year         = {2025},
      abstract     = {Current treatment of Parkinson's Disease (PD) remains
                      symptomatic, and disease-modifying approaches are urgently
                      required. A promising approach is to modify intestinal
                      microbiota and key metabolites of bacterial fermentation:
                      short-chain fatty acids (SCFA), which are decreased in PD. A
                      prospective, controlled pilot study (DRKS00034528) was
                      conducted on 11 couples (PD patient plus healthy spouse as
                      control (CO)). Participants followed a 4-week diet rich in
                      dietary fibre, including intake of the prebiotic Lactulose.
                      Gut metagenomes, faecal and urinary metabolites, and
                      clinical characteristics were assessed. The dietary
                      intervention significantly augmented faecal SCFA and
                      increased Bifidobacteria spp., reducing PD-related
                      gastrointestinal symptoms. The pre-existing bacterial
                      dysbiosis in PD (depletion of Blautia, Dorea,
                      Erysipelatoclostridium) persisted. Bacterial metabolite
                      composition in faeces and urine positively changed with the
                      intervention: Brain-relevant gut metabolic functions
                      involved in neuroprotective and antioxidant pathways,
                      including S-adenosyl methionine, glutathione, and inositol,
                      improved in PD. These promising results warrant further
                      investigation in larger cohorts.},
      cin          = {AG Wüllner},
      ddc          = {610},
      cid          = {I:(DE-2719)1011302},
      pnm          = {353 - Clinical and Health Care Research (POF4-353)},
      pid          = {G:(DE-HGF)POF4-353},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:40180909},
      pmc          = {pmc:PMC11968880},
      doi          = {10.1038/s41531-025-00885-5},
      url          = {https://pub.dzne.de/record/277883},
}