Home > Publications Database > Loss of Ten1 in mice induces telomere shortening and models human dyskeratosis congenita. > print

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082 _ _ |a 500
100 1 _ |a Sanz-Moreno, Adrián
|0 0000-0001-9478-5432
|b 0
245 _ _ |a Loss of Ten1 in mice induces telomere shortening and models human dyskeratosis congenita.
260 _ _ |a Washington, DC [u.a.]
|c 2025
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520 _ _ |a Telomere length regulation is essential for genome stability as short telomeres can trigger cellular senescence and apoptosis constituting an integral aspect of biological aging. Telomere biology disorders (TBDs) such as dyskeratosis congenita (DC) are rare, inherited diseases with known mutations in at least 16 different genes encoding components of the telomere maintenance complexes. The precise role of TEN1, part of the CST complex (CTC1, STN1, and TEN1), and the consequences of its loss of function in vivo are not yet known. We investigated the first viable murine model of Ten1 deficiency created by CRISPR-Cas9-mediated exon 3 deletion. Ten1 homozygous knockout mice present with telomere attrition, short life span, skin hyperpigmentation, aplastic anemia, and cerebellar hypoplasia. Molecular analyses revealed a reduction of proliferating cells, increased apoptosis, and stem cell depletion with activation of the p53/p21 signaling pathway. Our data demonstrate that Ten1 deficiency causes telomere shortening and associates with accelerated aging.
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650 _ 7 |a Tumor Suppressor Protein p53
|2 NLM Chemicals
650 _ 7 |a Telomere-Binding Proteins
|2 NLM Chemicals
650 _ 2 |a Animals
|2 MeSH
650 _ 2 |a Dyskeratosis Congenita: genetics
|2 MeSH
650 _ 2 |a Dyskeratosis Congenita: pathology
|2 MeSH
650 _ 2 |a Dyskeratosis Congenita: metabolism
|2 MeSH
650 _ 2 |a Mice
|2 MeSH
650 _ 2 |a Telomere Shortening: genetics
|2 MeSH
650 _ 2 |a Disease Models, Animal
|2 MeSH
650 _ 2 |a Mice, Knockout
|2 MeSH
650 _ 2 |a Humans
|2 MeSH
650 _ 2 |a Apoptosis: genetics
|2 MeSH
650 _ 2 |a Tumor Suppressor Protein p53: metabolism
|2 MeSH
650 _ 2 |a Telomere: genetics
|2 MeSH
650 _ 2 |a Telomere: metabolism
|2 MeSH
650 _ 2 |a Telomere-Binding Proteins: genetics
|2 MeSH
650 _ 2 |a Telomere-Binding Proteins: deficiency
|2 MeSH
650 _ 2 |a Signal Transduction
|2 MeSH
700 1 _ |a Becker, Lore
|0 0000-0002-6890-4984
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700 1 _ |a Xie, Kan
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700 1 _ |a da Silva-Buttkus, Patricia
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700 1 _ |a Dragano, Nathalia R V
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700 1 _ |a Aguilar-Pimentel, Antonio
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700 1 _ |a Amarie, Oana V
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700 1 _ |a Calzada-Wack, Julia
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700 1 _ |a Kraiger, Markus
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700 1 _ |a Leuchtenberger, Stefanie
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700 1 _ |a Seisenberger, Claudia
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700 1 _ |a Marschall, Susan
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700 1 _ |a Rathkolb, Birgit
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700 1 _ |a Scifo, Enzo
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700 1 _ |a Liu, Ting
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700 1 _ |a Thanabalasingam, Anoja
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700 1 _ |a Sanchez-Vazquez, Raul
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700 1 _ |a Martinez, Paula
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700 1 _ |a Blasco, Maria A
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700 1 _ |a Savage, Sharon A
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700 1 _ |a Fuchs, Helmut
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700 1 _ |a Ehninger, Dan
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700 1 _ |a Gailus-Durner, Valérie
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700 1 _ |a de Angelis, Martin Hrabê
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773 _ _ |a 10.1126/sciadv.adp8093
|g Vol. 11, no. 15, p. eadp8093
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