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000277991 1001_ $$0P:(DE-2719)2812832$$aKaurani, Lalit$$b0$$eFirst author
000277991 245__ $$aA role for astrocytic miR-129-5p in frontotemporal dementia.
000277991 260__ $$aLondon$$bNature Publishing Group$$c2025
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000277991 520__ $$aFrontotemporal dementia is a debilitating neurodegenerative disorder characterized by frontal and temporal lobe degeneration, resulting in behavioral changes, language difficulties, and cognitive decline. In this study, smallRNA sequencing was conducted on postmortem brain tissues obtained from the frontal and temporal of FTD patients with GRN, MAPT, or C9ORF72 mutations. Our analysis identified miR-129-5p as consistently deregulated across all analyzed mutation conditions and brain regions. Functional investigations in in-vitro models revealed a novel role of miR-129-5p in astrocytes, where its loss led to neuroinflammation and impaired neuronal support functions, including reduced glutamate uptake. Depletion of miR-129-5p in astrocytes also resulted in the loss of neuronal spines and altered neuronal network activity in a cell culture system. These findings highlight miR-129-5p as a potential therapeutic target in neurodegenerative diseases and also sheds light on the role of astrocytes in Frontotemporal dementia pathogenesis.
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000277991 650_7 $$2NLM Chemicals$$aMicroRNAs
000277991 650_7 $$2NLM Chemicals$$atau Proteins
000277991 650_7 $$2NLM Chemicals$$aMirn129 microRNA, human
000277991 650_7 $$2NLM Chemicals$$aMAPT protein, human
000277991 650_7 $$2NLM Chemicals$$aC9orf72 Protein
000277991 650_7 $$2NLM Chemicals$$aProgranulins
000277991 650_7 $$2NLM Chemicals$$aGRN protein, human
000277991 650_7 $$2NLM Chemicals$$aC9orf72 protein, human
000277991 650_7 $$03KX376GY7L$$2NLM Chemicals$$aGlutamic Acid
000277991 650_2 $$2MeSH$$aHumans
000277991 650_2 $$2MeSH$$aFrontotemporal Dementia: genetics
000277991 650_2 $$2MeSH$$aFrontotemporal Dementia: metabolism
000277991 650_2 $$2MeSH$$aFrontotemporal Dementia: pathology
000277991 650_2 $$2MeSH$$aAstrocytes: metabolism
000277991 650_2 $$2MeSH$$aMicroRNAs: genetics
000277991 650_2 $$2MeSH$$aMicroRNAs: metabolism
000277991 650_2 $$2MeSH$$atau Proteins: genetics
000277991 650_2 $$2MeSH$$aMale
000277991 650_2 $$2MeSH$$aFemale
000277991 650_2 $$2MeSH$$aC9orf72 Protein: genetics
000277991 650_2 $$2MeSH$$aProgranulins: genetics
000277991 650_2 $$2MeSH$$aMiddle Aged
000277991 650_2 $$2MeSH$$aMutation
000277991 650_2 $$2MeSH$$aAged
000277991 650_2 $$2MeSH$$aBrain: metabolism
000277991 650_2 $$2MeSH$$aGlutamic Acid: metabolism
000277991 7001_ $$0P:(DE-2719)9001438$$aPradhan, Ranjit$$b1$$udzne
000277991 7001_ $$0P:(DE-2719)9001406$$aSchröder, Sophie$$b2
000277991 7001_ $$0P:(DE-2719)2810773$$aBurkhardt, Susanne$$b3$$udzne
000277991 7001_ $$0P:(DE-2719)2810585$$aSchuetz, Anna-Lena$$b4$$udzne
000277991 7001_ $$0P:(DE-2719)2812548$$aKrüger, Dennis M$$b5
000277991 7001_ $$0P:(DE-2719)2811063$$aPena, Tonatiuh$$b6
000277991 7001_ $$0P:(DE-2719)2810728$$aHeutink, Peter$$b7
000277991 7001_ $$0P:(DE-2719)2811099$$aSananbenesi, Farahnaz$$b8$$udzne
000277991 7001_ $$0P:(DE-2719)2000047$$aFischer, Andre$$b9$$eLast author
000277991 773__ $$0PERI:(DE-600)2609311-X$$a10.1038/s41398-025-03338-y$$gVol. 15, no. 1, p. 142$$n1$$p142$$tTranslational Psychiatry$$v15$$x2158-3188$$y2025
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