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@ARTICLE{Kaurani:277991,
      author       = {Kaurani, Lalit and Pradhan, Ranjit and Schröder, Sophie
                      and Burkhardt, Susanne and Schuetz, Anna-Lena and Krüger,
                      Dennis M and Pena, Tonatiuh and Heutink, Peter and
                      Sananbenesi, Farahnaz and Fischer, Andre},
      title        = {{A} role for astrocytic mi{R}-129-5p in frontotemporal
                      dementia.},
      journal      = {Translational Psychiatry},
      volume       = {15},
      number       = {1},
      issn         = {2158-3188},
      address      = {London},
      publisher    = {Nature Publishing Group},
      reportid     = {DZNE-2025-00518},
      pages        = {142},
      year         = {2025},
      abstract     = {Frontotemporal dementia is a debilitating neurodegenerative
                      disorder characterized by frontal and temporal lobe
                      degeneration, resulting in behavioral changes, language
                      difficulties, and cognitive decline. In this study, smallRNA
                      sequencing was conducted on postmortem brain tissues
                      obtained from the frontal and temporal of FTD patients with
                      GRN, MAPT, or C9ORF72 mutations. Our analysis identified
                      miR-129-5p as consistently deregulated across all analyzed
                      mutation conditions and brain regions. Functional
                      investigations in in-vitro models revealed a novel role of
                      miR-129-5p in astrocytes, where its loss led to
                      neuroinflammation and impaired neuronal support functions,
                      including reduced glutamate uptake. Depletion of miR-129-5p
                      in astrocytes also resulted in the loss of neuronal spines
                      and altered neuronal network activity in a cell culture
                      system. These findings highlight miR-129-5p as a potential
                      therapeutic target in neurodegenerative diseases and also
                      sheds light on the role of astrocytes in Frontotemporal
                      dementia pathogenesis.},
      keywords     = {Humans / Frontotemporal Dementia: genetics / Frontotemporal
                      Dementia: metabolism / Frontotemporal Dementia: pathology /
                      Astrocytes: metabolism / MicroRNAs: genetics / MicroRNAs:
                      metabolism / tau Proteins: genetics / Male / Female /
                      C9orf72 Protein: genetics / Progranulins: genetics / Middle
                      Aged / Mutation / Aged / Brain: metabolism / Glutamic Acid:
                      metabolism / MicroRNAs (NLM Chemicals) / tau Proteins (NLM
                      Chemicals) / Mirn129 microRNA, human (NLM Chemicals) / MAPT
                      protein, human (NLM Chemicals) / C9orf72 Protein (NLM
                      Chemicals) / Progranulins (NLM Chemicals) / GRN protein,
                      human (NLM Chemicals) / C9orf72 protein, human (NLM
                      Chemicals) / Glutamic Acid (NLM Chemicals)},
      cin          = {AG Fischer / Clinical Dementia Research (Göttingen) / AG
                      Sananbenesi / Bioinformatics Unit (Göttingen)},
      ddc          = {610},
      cid          = {I:(DE-2719)1410002 / I:(DE-2719)1440015 /
                      I:(DE-2719)1410004 / I:(DE-2719)1440016},
      pnm          = {352 - Disease Mechanisms (POF4-352) / 353 - Clinical and
                      Health Care Research (POF4-353) / 899 - ohne Topic
                      (POF4-899)},
      pid          = {G:(DE-HGF)POF4-352 / G:(DE-HGF)POF4-353 /
                      G:(DE-HGF)POF4-899},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:40216778},
      pmc          = {pmc:PMC11992244},
      doi          = {10.1038/s41398-025-03338-y},
      url          = {https://pub.dzne.de/record/277991},
}