TY  - JOUR
AU  - Kersting, Lennart N
AU  - Walger, Lennart
AU  - Bauer, Tobias
AU  - Gnatkovsky, Vadym
AU  - Schuch, Fabiane
AU  - David, Bastian
AU  - Neuhaus, Elisabeth
AU  - Keil, Fee
AU  - Tietze, Anna
AU  - Rosenow, Felix
AU  - Kaindl, Angela M
AU  - Hattingen, Elke
AU  - Huppertz, Hans-Jürgen
AU  - Radbruch, Alexander
AU  - Surges, Rainer
AU  - Rüber, Theodor
TI  - Detection of focal cortical dysplasia: Development and multicentric evaluation of artificial intelligence models.
JO  - Epilepsia
VL  - 66
IS  - 4
SN  - 0013-9580
CY  - Oxford [u.a.]
PB  - Wiley-Blackwell
M1  - DZNE-2025-00530
SP  - 1165 - 1176
PY  - 2025
AB  - Focal cortical dysplasia (FCD) is a common cause of drug-resistant focal epilepsy but can be challenging to detect visually on magnetic resonance imaging. Three artificial intelligence models for automated FCD detection are publicly available (MAP18, deepFCD, MELD) but have only been compared on single-center data. Our first objective is to compare them on independent multicenter test data. Additionally, we train and compare three new models and make them publicly available.We retrospectively collected FCD cases from four epilepsy centers. We chose three novel models that take two-dimensional (2D) slices (2D-nnUNet), 2.5D slices (FastSurferCNN), and large 3D patches (3D-nnUNet) as inputs and trained them on a subset of Bonn data. As core evaluation metrics, we used voxel-level Dice similarity coefficient (DSC), cluster-level F1 score, subject-level detection rate, and specificity.We collected 329 subjects, 244 diagnosed with FCD (27.7 ± 14.4 years old, 54
KW  - Humans
KW  - Male
KW  - Female
KW  - Malformations of Cortical Development: diagnostic imaging
KW  - Adult
KW  - Magnetic Resonance Imaging: methods
KW  - Retrospective Studies
KW  - Young Adult
KW  - Child
KW  - Artificial Intelligence
KW  - Adolescent
KW  - Imaging, Three-Dimensional
KW  - Focal Cortical Dysplasia
KW  - MRI (Other)
KW  - computer‐aided detection (Other)
KW  - epilepsy (Other)
KW  - lesion detection (Other)
KW  - model comparison (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:39739580
C2  - pmc:PMC11997906
DO  - DOI:10.1111/epi.18240
UR  - https://pub.dzne.de/record/278020
ER  -