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000278026 041__ $$aEnglish
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000278026 1001_ $$aSchneeberger, Shirin$$b0
000278026 245__ $$aInterleukin-12 signaling drives Alzheimer's disease pathology through disrupting neuronal and oligodendrocyte homeostasis.
000278026 260__ $$aLondon$$bNature Research$$c2025
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000278026 520__ $$aNeuroinflammation including interleukin (IL)-12/IL-23-signaling is central to Alzheimer's disease (AD) pathology. Inhibition of p40, a subunit of IL-12/IL-23, attenuates pathology in AD-like mice; however, its signaling mechanism and expression pattern remained elusive. Here we show that IL-12 receptors are predominantly expressed in neurons and oligodendrocytes in AD-like APPPS1 mice and in patients with AD, whereas IL-23 receptor transcripts are barely detectable. Consistently, deletion of the IL-12 receptor in neuroectodermal cells ameliorated AD pathology in APPPS1 mice, whereas removal of IL-23 receptors had no effect. Genetic ablation of IL-12 signaling alone reverted the loss of mature oligodendrocytes, restored myelin homeostasis, rescued the amyloid-β-dependent reduction of parvalbumin-positive interneurons and restored phagocytosis-related changes in microglia of APPPS1 mice. Furthermore, IL-12 protein expression was increased in human AD brains compared to healthy age-matched controls, and human oligodendrocyte-like cells responded profoundly to IL-12 stimulation. We conclude that oligodendroglial and neuronal IL-12 signaling, but not IL-23 signaling, are key in orchestrating AD-related neuroimmune crosstalk and that IL-12 represents an attractive therapeutic target in AD.
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000278026 650_7 $$0187348-17-0$$2NLM Chemicals$$aInterleukin-12
000278026 650_7 $$2NLM Chemicals$$aReceptors, Interleukin-12
000278026 650_7 $$2NLM Chemicals$$aAmyloid beta-Peptides
000278026 650_7 $$2NLM Chemicals$$aReceptors, Interleukin
000278026 650_7 $$2NLM Chemicals$$aAmyloid beta-Protein Precursor
000278026 650_2 $$2MeSH$$aAlzheimer Disease: pathology
000278026 650_2 $$2MeSH$$aAlzheimer Disease: metabolism
000278026 650_2 $$2MeSH$$aAlzheimer Disease: immunology
000278026 650_2 $$2MeSH$$aAlzheimer Disease: genetics
000278026 650_2 $$2MeSH$$aAnimals
000278026 650_2 $$2MeSH$$aHumans
000278026 650_2 $$2MeSH$$aSignal Transduction
000278026 650_2 $$2MeSH$$aMice
000278026 650_2 $$2MeSH$$aOligodendroglia: metabolism
000278026 650_2 $$2MeSH$$aOligodendroglia: pathology
000278026 650_2 $$2MeSH$$aHomeostasis
000278026 650_2 $$2MeSH$$aNeurons: metabolism
000278026 650_2 $$2MeSH$$aNeurons: pathology
000278026 650_2 $$2MeSH$$aInterleukin-12: metabolism
000278026 650_2 $$2MeSH$$aInterleukin-12: genetics
000278026 650_2 $$2MeSH$$aMice, Transgenic
000278026 650_2 $$2MeSH$$aMale
000278026 650_2 $$2MeSH$$aReceptors, Interleukin-12: metabolism
000278026 650_2 $$2MeSH$$aReceptors, Interleukin-12: genetics
000278026 650_2 $$2MeSH$$aBrain: pathology
000278026 650_2 $$2MeSH$$aBrain: metabolism
000278026 650_2 $$2MeSH$$aDisease Models, Animal
000278026 650_2 $$2MeSH$$aFemale
000278026 650_2 $$2MeSH$$aMicroglia: metabolism
000278026 650_2 $$2MeSH$$aAged
000278026 650_2 $$2MeSH$$aAmyloid beta-Peptides: metabolism
000278026 650_2 $$2MeSH$$aReceptors, Interleukin: metabolism
000278026 650_2 $$2MeSH$$aReceptors, Interleukin: genetics
000278026 650_2 $$2MeSH$$aAmyloid beta-Protein Precursor: genetics
000278026 7001_ $$aKim, Seung Joon$$b1
000278026 7001_ $$aGeesdorf, Maria N$$b2
000278026 7001_ $$0P:(DE-2719)9002758$$aFriebel, Ekaterina$$b3$$udzne
000278026 7001_ $$aEede, Pascale$$b4
000278026 7001_ $$00000-0002-8601-2277$$aJendrach, Marina$$b5
000278026 7001_ $$00000-0002-8356-9766$$aBoltengagen, Anastasiya$$b6
000278026 7001_ $$aBraeuning, Caroline$$b7
000278026 7001_ $$00000-0002-9535-9395$$aRuhwedel, Torben$$b8
000278026 7001_ $$00000-0001-6987-8979$$aHülsmeier, Andreas J$$b9
000278026 7001_ $$00000-0001-9456-3063$$aGimber, Niclas$$b10
000278026 7001_ $$aFoerster, Marlene$$b11
000278026 7001_ $$aObst, Juliane$$b12
000278026 7001_ $$00000-0001-6757-4664$$aAndreadou, Myrto$$b13
000278026 7001_ $$00000-0003-2169-2109$$aMundt, Sarah$$b14
000278026 7001_ $$aSchmoranzer, Jan$$b15
000278026 7001_ $$aProkop, Stefan$$b16
000278026 7001_ $$aKessler, Wiebke$$b17
000278026 7001_ $$aKuhlmann, Tanja$$b18
000278026 7001_ $$00000-0002-2902-7165$$aMöbius, Wiebke$$b19
000278026 7001_ $$00000-0001-8724-9666$$aNave, Klaus-Armin$$b20
000278026 7001_ $$00000-0002-4218-1087$$aHornemann, Thorsten$$b21
000278026 7001_ $$00000-0002-1541-7867$$aBecher, Burkhard$$b22
000278026 7001_ $$00000-0002-3869-0962$$aEdgar, Julia M$$b23
000278026 7001_ $$00000-0001-7771-3947$$aKaraiskos, Nikos$$b24
000278026 7001_ $$00000-0003-1749-3334$$aKocks, Christine$$b25
000278026 7001_ $$00000-0002-4785-4332$$aRajewsky, Nikolaus$$b26
000278026 7001_ $$0P:(DE-2719)2812386$$aHeppner, Frank L$$b27$$eLast author
000278026 773__ $$0PERI:(DE-600)3029419-8$$a10.1038/s43587-025-00816-2$$gVol. 5, no. 4, p. 622 - 641$$n4$$p622 - 641$$tNature aging$$v5$$x2662-8465$$y2025
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