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000278044 041__ $$aEnglish
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000278044 1001_ $$aMoussiopoulou, Joanna$$b0
000278044 245__ $$aHigher blood-brain barrier leakage in schizophrenia-spectrum disorders: A comparative dynamic contrast-enhanced magnetic resonance imaging study with healthy controls.
000278044 260__ $$aOrlando, Fla. [u.a.]$$bElsevier$$c2025
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000278044 520__ $$aBlood-brain barrier (BBB) disruptions are presumed to be implicated in schizophrenia-spectrum disorders (SSDs). Previous studies focused on cerebrospinal fluid (CSF) markers, which are imprecise for detecting subtle BBB disruption. Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) enables sensitive investigation of subtle BBB leakage in vivo, yet remains unexplored in SSD research. We hypothesized higher leakage in SSDs compared to healthy controls (HCs), indicating a clinical sub-phenotype.Forty-one people with SSDs and forty age- and sex-matched HCs were included in this cross-sectional study employing DCE-MRI, clinical characterization, cognitive assessment, blood and CSF analyses. The volume transfer constant Ktrans, calculated using the Patlak method to estimate the contrast agent transfer between blood and extravascular space, was compared between groups to detect differences in BBB leakage.Individuals with SSDs showed higher BBB leakage compared to HCs in a widespread pattern, in brain regions typically affected in SSDs. No significant association was detected between leakage and measures of cognition, symptom severity, peripheral inflammation markers and albumin CSF/serum ratio.This is the first study to date reporting BBB leakage in SSDs compared to HCs in multiple brain regions implicated in the disorder. These findings provide insights into disease mechanisms, highlighting the need for further investigation into the role of the BBB in SSDs.
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000278044 650_7 $$2Other$$aBBB
000278044 650_7 $$2Other$$aDCE-MRI
000278044 650_7 $$2Other$$aLeakage
000278044 650_7 $$2Other$$aNeuroimaging
000278044 650_7 $$2Other$$aSSD
000278044 650_7 $$2Other$$aSchizophrenia
000278044 7001_ $$aYakimov, Vladislav$$b1
000278044 7001_ $$aRoell, Lukas$$b2
000278044 7001_ $$0P:(DE-2719)9001808$$aRauchmann, Boris Stephan$$b3$$udzne
000278044 7001_ $$aToth, Hannah$$b4
000278044 7001_ $$aMelcher, Julian$$b5
000278044 7001_ $$aJäger, Iris$$b6
000278044 7001_ $$aLutz, Isabel$$b7
000278044 7001_ $$aKallweit, Marcel S$$b8
000278044 7001_ $$aPapazov, Boris$$b9
000278044 7001_ $$aBoudriot, Emanuel$$b10
000278044 7001_ $$aSeelos, Klaus$$b11
000278044 7001_ $$aDehsarvi, Amir$$b12
000278044 7001_ $$aCampana, Mattia$$b13
000278044 7001_ $$aRaabe, Florian$$b14
000278044 7001_ $$aMaurus, Isabel$$b15
000278044 7001_ $$aLöhrs, Lisa$$b16
000278044 7001_ $$0P:(DE-2719)9001539$$aBrendel, Matthias$$b17$$udzne
000278044 7001_ $$aStöcklein, Sophia$$b18
000278044 7001_ $$aFalkai, Peter$$b19
000278044 7001_ $$aHasan, Alkomiet$$b20
000278044 7001_ $$aGroup, Cdp Working$$b21
000278044 7001_ $$aFranzmeier, Nicolai$$b22
000278044 7001_ $$aKeeser, Daniel$$b23
000278044 7001_ $$aWagner, Elias$$b24
000278044 773__ $$0PERI:(DE-600)1462491-6$$a10.1016/j.bbi.2025.04.003$$gVol. 128, p. 256 - 265$$p256 - 265$$tBrain, behavior and immunity$$v128$$x0889-1591$$y2025
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