% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{Moussiopoulou:278044,
      author       = {Moussiopoulou, Joanna and Yakimov, Vladislav and Roell,
                      Lukas and Rauchmann, Boris Stephan and Toth, Hannah and
                      Melcher, Julian and Jäger, Iris and Lutz, Isabel and
                      Kallweit, Marcel S and Papazov, Boris and Boudriot, Emanuel
                      and Seelos, Klaus and Dehsarvi, Amir and Campana, Mattia and
                      Raabe, Florian and Maurus, Isabel and Löhrs, Lisa and
                      Brendel, Matthias and Stöcklein, Sophia and Falkai, Peter
                      and Hasan, Alkomiet and Group, Cdp Working and Franzmeier,
                      Nicolai and Keeser, Daniel and Wagner, Elias},
      title        = {{H}igher blood-brain barrier leakage in
                      schizophrenia-spectrum disorders: {A} comparative dynamic
                      contrast-enhanced magnetic resonance imaging study with
                      healthy controls.},
      journal      = {Brain, behavior and immunity},
      volume       = {128},
      issn         = {0889-1591},
      address      = {Orlando, Fla. [u.a.]},
      publisher    = {Elsevier},
      reportid     = {DZNE-2025-00550},
      pages        = {256 - 265},
      year         = {2025},
      abstract     = {Blood-brain barrier (BBB) disruptions are presumed to be
                      implicated in schizophrenia-spectrum disorders (SSDs).
                      Previous studies focused on cerebrospinal fluid (CSF)
                      markers, which are imprecise for detecting subtle BBB
                      disruption. Dynamic contrast-enhanced magnetic resonance
                      imaging (DCE-MRI) enables sensitive investigation of subtle
                      BBB leakage in vivo, yet remains unexplored in SSD research.
                      We hypothesized higher leakage in SSDs compared to healthy
                      controls (HCs), indicating a clinical
                      sub-phenotype.Forty-one people with SSDs and forty age- and
                      sex-matched HCs were included in this cross-sectional study
                      employing DCE-MRI, clinical characterization, cognitive
                      assessment, blood and CSF analyses. The volume transfer
                      constant Ktrans, calculated using the Patlak method to
                      estimate the contrast agent transfer between blood and
                      extravascular space, was compared between groups to detect
                      differences in BBB leakage.Individuals with SSDs showed
                      higher BBB leakage compared to HCs in a widespread pattern,
                      in brain regions typically affected in SSDs. No significant
                      association was detected between leakage and measures of
                      cognition, symptom severity, peripheral inflammation markers
                      and albumin CSF/serum ratio.This is the first study to date
                      reporting BBB leakage in SSDs compared to HCs in multiple
                      brain regions implicated in the disorder. These findings
                      provide insights into disease mechanisms, highlighting the
                      need for further investigation into the role of the BBB in
                      SSDs.},
      keywords     = {BBB (Other) / DCE-MRI (Other) / Leakage (Other) /
                      Neuroimaging (Other) / SSD (Other) / Schizophrenia (Other)},
      cin          = {AG Haass},
      ddc          = {150},
      cid          = {I:(DE-2719)1110007},
      pnm          = {352 - Disease Mechanisms (POF4-352)},
      pid          = {G:(DE-HGF)POF4-352},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:40194748},
      doi          = {10.1016/j.bbi.2025.04.003},
      url          = {https://pub.dzne.de/record/278044},
}