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000278067 037__ $$aDZNE-2025-00558
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000278067 1001_ $$aKaiser, Kim M$$b0
000278067 245__ $$aIL-17A-producing NKp44(-) group 3 innate lymphoid cells accumulate in Familial Adenomatous Polyposis duodenal tissue.
000278067 260__ $$a[London]$$bSpringer Nature$$c2025
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000278067 520__ $$aFamilial adenomatous polyposis (FAP) is an inherited gastrointestinal syndrome associated with duodenal adenoma formation. Even among carriers of the same genetic variant, duodenal phenotypes vary, indicating that additional factors, such as the local immune system, play a role. We observe an increase in duodenal IL-17A(+)NKp44(-) innate lymphoid type 3 cell (ILC3) in FAP, localized near the epithelium and enriched in adenomas and carcinomas. Elevated IL1B, IL23A, and DLL4 transcript levels correlate with IL-17A(+)NKp44(-)ILC3 accumulation, and in vitro studies with duodenal organoids confirmed this relationship. Bulk RNA sequencing reveals upregulated Reactive oxygen species (ROS)-inducing enzymes DUOX2 and DUOXA2 in FAP adenomas. IL-17A-stimulated FAP organoids show increased DUOX2/DUOXA2 expression, Duox2 protein, and ROS production, leading to DNA damage, suggesting a mechanism by which these immune cells promote tumorigenesis. These findings suggest IL-17A(+)NKp44(-)ILC3s may contribute to a local environment that makes the epithelium more submissive for oncogenic transformation in FAP.
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000278067 650_7 $$2NLM Chemicals$$aInterleukin-17
000278067 650_7 $$0EC 1.11.1.-$$2NLM Chemicals$$aDual Oxidases
000278067 650_7 $$0EC 1.6.3.1$$2NLM Chemicals$$aDUOX2 protein, human
000278067 650_7 $$2NLM Chemicals$$aReactive Oxygen Species
000278067 650_7 $$2NLM Chemicals$$aIL17A protein, human
000278067 650_7 $$2NLM Chemicals$$aInterleukin-23 Subunit p19
000278067 650_7 $$2NLM Chemicals$$aIL23A protein, human
000278067 650_7 $$2NLM Chemicals$$aInterleukin-1beta
000278067 650_7 $$0EC 1.6.3.-$$2NLM Chemicals$$aNADPH Oxidases
000278067 650_7 $$2NLM Chemicals$$aIL1B protein, human
000278067 650_7 $$2NLM Chemicals$$aMembrane Proteins
000278067 650_2 $$2MeSH$$aInterleukin-17: metabolism
000278067 650_2 $$2MeSH$$aInterleukin-17: genetics
000278067 650_2 $$2MeSH$$aInterleukin-17: immunology
000278067 650_2 $$2MeSH$$aHumans
000278067 650_2 $$2MeSH$$aDual Oxidases
000278067 650_2 $$2MeSH$$aAdenomatous Polyposis Coli: immunology
000278067 650_2 $$2MeSH$$aAdenomatous Polyposis Coli: genetics
000278067 650_2 $$2MeSH$$aAdenomatous Polyposis Coli: pathology
000278067 650_2 $$2MeSH$$aAdenomatous Polyposis Coli: metabolism
000278067 650_2 $$2MeSH$$aLymphocytes: immunology
000278067 650_2 $$2MeSH$$aLymphocytes: metabolism
000278067 650_2 $$2MeSH$$aReactive Oxygen Species: metabolism
000278067 650_2 $$2MeSH$$aDuodenum: pathology
000278067 650_2 $$2MeSH$$aDuodenum: immunology
000278067 650_2 $$2MeSH$$aDuodenum: metabolism
000278067 650_2 $$2MeSH$$aImmunity, Innate
000278067 650_2 $$2MeSH$$aMale
000278067 650_2 $$2MeSH$$aInterleukin-23 Subunit p19: genetics
000278067 650_2 $$2MeSH$$aInterleukin-23 Subunit p19: metabolism
000278067 650_2 $$2MeSH$$aFemale
000278067 650_2 $$2MeSH$$aInterleukin-1beta: genetics
000278067 650_2 $$2MeSH$$aInterleukin-1beta: metabolism
000278067 650_2 $$2MeSH$$aDuodenal Neoplasms: immunology
000278067 650_2 $$2MeSH$$aDuodenal Neoplasms: pathology
000278067 650_2 $$2MeSH$$aDuodenal Neoplasms: genetics
000278067 650_2 $$2MeSH$$aDuodenal Neoplasms: metabolism
000278067 650_2 $$2MeSH$$aOrganoids: metabolism
000278067 650_2 $$2MeSH$$aNADPH Oxidases: metabolism
000278067 650_2 $$2MeSH$$aNADPH Oxidases: genetics
000278067 650_2 $$2MeSH$$aMembrane Proteins: genetics
000278067 650_2 $$2MeSH$$aMembrane Proteins: metabolism
000278067 650_2 $$2MeSH$$aDNA Damage
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000278067 7001_ $$aRaabe, Jan$$b1
000278067 7001_ $$aToVinh, Michael$$b2
000278067 7001_ $$aHack, Gudrun$$b3
000278067 7001_ $$aAhmad, Sarah$$b4
000278067 7001_ $$aMüller, Niko$$b5
000278067 7001_ $$aCassella, Julia$$b6
000278067 7001_ $$aWalravens, Sofia I$$b7
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000278067 7001_ $$aArias Garcia, Lauren$$b9
000278067 7001_ $$00000-0003-0093-7832$$aKaczmarek, Dominik J$$b10
000278067 7001_ $$aMarwitz, Tim$$b11
000278067 7001_ $$aGoeser, Felix$$b12
000278067 7001_ $$aNischalke, Hans Dieter$$b13
000278067 7001_ $$aLutz, Philipp$$b14
000278067 7001_ $$00000-0002-1370-1573$$aSommer, Nils$$b15
000278067 7001_ $$aVilz, Tim$$b16
000278067 7001_ $$aToma, Marieta$$b17
000278067 7001_ $$aSteiner, Susanne$$b18
000278067 7001_ $$aHommerding, Oliver$$b19
000278067 7001_ $$00000-0002-1585-4100$$aOldenburg, Johannes$$b20
000278067 7001_ $$00000-0003-4048-8824$$aHölzel, Michael$$b21
000278067 7001_ $$00009-0005-3226-5219$$aKadzik, Sebastian$$b22
000278067 7001_ $$aMaas, Alexander$$b23
000278067 7001_ $$aEckrich, Jonas$$b24
000278067 7001_ $$aZumfelde, Philipp$$b25
000278067 7001_ $$00000-0003-1161-1942$$aShakeri, Farhad$$b26
000278067 7001_ $$00000-0003-3098-3928$$aNesic, Svetozar$$b27
000278067 7001_ $$aBuness, Andreas$$b28
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000278067 7001_ $$0P:(DE-2719)2812750$$aBecker, Matthias$$b30
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000278067 7001_ $$0P:(DE-2719)2812913$$aAschenbrenner, Anna C$$b33
000278067 7001_ $$aSteinheuer, Lisa M$$b34
000278067 7001_ $$00000-0002-7217-2755$$aThurley, Kevin$$b35
000278067 7001_ $$aKroh, Sandy$$b36
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000278067 7001_ $$00000-0001-7167-8431$$aGohr, Florian N$$b39
000278067 7001_ $$00000-0002-9979-9769$$aSchmidt, Florian I$$b40
000278067 7001_ $$aWang, Danni$$b41
000278067 7001_ $$00000-0001-7057-6935$$aHeld, Kathrin$$b42
000278067 7001_ $$aBaranov, Olga$$b43
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000278067 7001_ $$aStrassburg, Christian P$$b45
000278067 7001_ $$aHüneburg, Robert$$b46
000278067 7001_ $$00000-0002-1385-9709$$aKrämer, Benjamin$$b47
000278067 7001_ $$00000-0001-5972-0780$$aNattermann, Jacob$$b48
000278067 773__ $$0PERI:(DE-600)2553671-0$$a10.1038/s41467-025-58907-y$$gVol. 16, no. 1, p. 3873$$n1$$p3873$$tNature Communications$$v16$$x2041-1723$$y2025
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