% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{Kaiser:278067,
      author       = {Kaiser, Kim M and Raabe, Jan and ToVinh, Michael and Hack,
                      Gudrun and Ahmad, Sarah and Müller, Niko and Cassella,
                      Julia and Walravens, Sofia I and Alfaro, Paula and Arias
                      Garcia, Lauren and Kaczmarek, Dominik J and Marwitz, Tim and
                      Goeser, Felix and Nischalke, Hans Dieter and Lutz, Philipp
                      and Sommer, Nils and Vilz, Tim and Toma, Marieta and
                      Steiner, Susanne and Hommerding, Oliver and Oldenburg,
                      Johannes and Hölzel, Michael and Kadzik, Sebastian and
                      Maas, Alexander and Eckrich, Jonas and Zumfelde, Philipp and
                      Shakeri, Farhad and Nesic, Svetozar and Buness, Andreas and
                      De Caro, Emilia and Becker, Matthias and Beyer, Marc D and
                      Ulas, Thomas and Aschenbrenner, Anna C and Steinheuer, Lisa
                      M and Thurley, Kevin and Kroh, Sandy and Uecker, Ralf and
                      Hauser, Anja E and Gohr, Florian N and Schmidt, Florian I
                      and Wang, Danni and Held, Kathrin and Baranov, Olga and
                      Geldmacher, Christof and Strassburg, Christian P and
                      Hüneburg, Robert and Krämer, Benjamin and Nattermann,
                      Jacob},
      title        = {{IL}-17{A}-producing {NK}p44(-) group 3 innate lymphoid
                      cells accumulate in {F}amilial {A}denomatous {P}olyposis
                      duodenal tissue.},
      journal      = {Nature Communications},
      volume       = {16},
      number       = {1},
      issn         = {2041-1723},
      address      = {[London]},
      publisher    = {Springer Nature},
      reportid     = {DZNE-2025-00558},
      pages        = {3873},
      year         = {2025},
      abstract     = {Familial adenomatous polyposis (FAP) is an inherited
                      gastrointestinal syndrome associated with duodenal adenoma
                      formation. Even among carriers of the same genetic variant,
                      duodenal phenotypes vary, indicating that additional
                      factors, such as the local immune system, play a role. We
                      observe an increase in duodenal IL-17A(+)NKp44(-) innate
                      lymphoid type 3 cell (ILC3) in FAP, localized near the
                      epithelium and enriched in adenomas and carcinomas. Elevated
                      IL1B, IL23A, and DLL4 transcript levels correlate with
                      IL-17A(+)NKp44(-)ILC3 accumulation, and in vitro studies
                      with duodenal organoids confirmed this relationship. Bulk
                      RNA sequencing reveals upregulated Reactive oxygen species
                      (ROS)-inducing enzymes DUOX2 and DUOXA2 in FAP adenomas.
                      IL-17A-stimulated FAP organoids show increased DUOX2/DUOXA2
                      expression, Duox2 protein, and ROS production, leading to
                      DNA damage, suggesting a mechanism by which these immune
                      cells promote tumorigenesis. These findings suggest
                      IL-17A(+)NKp44(-)ILC3s may contribute to a local environment
                      that makes the epithelium more submissive for oncogenic
                      transformation in FAP.},
      keywords     = {Interleukin-17: metabolism / Interleukin-17: genetics /
                      Interleukin-17: immunology / Humans / Dual Oxidases /
                      Adenomatous Polyposis Coli: immunology / Adenomatous
                      Polyposis Coli: genetics / Adenomatous Polyposis Coli:
                      pathology / Adenomatous Polyposis Coli: metabolism /
                      Lymphocytes: immunology / Lymphocytes: metabolism / Reactive
                      Oxygen Species: metabolism / Duodenum: pathology / Duodenum:
                      immunology / Duodenum: metabolism / Immunity, Innate / Male
                      / Interleukin-23 Subunit p19: genetics / Interleukin-23
                      Subunit p19: metabolism / Female / Interleukin-1beta:
                      genetics / Interleukin-1beta: metabolism / Duodenal
                      Neoplasms: immunology / Duodenal Neoplasms: pathology /
                      Duodenal Neoplasms: genetics / Duodenal Neoplasms:
                      metabolism / Organoids: metabolism / NADPH Oxidases:
                      metabolism / NADPH Oxidases: genetics / Membrane Proteins:
                      genetics / Membrane Proteins: metabolism / DNA Damage /
                      Interleukin-17 (NLM Chemicals) / Dual Oxidases (NLM
                      Chemicals) / DUOX2 protein, human (NLM Chemicals) / Reactive
                      Oxygen Species (NLM Chemicals) / IL17A protein, human (NLM
                      Chemicals) / Interleukin-23 Subunit p19 (NLM Chemicals) /
                      IL23A protein, human (NLM Chemicals) / Interleukin-1beta
                      (NLM Chemicals) / NADPH Oxidases (NLM Chemicals) / IL1B
                      protein, human (NLM Chemicals) / Membrane Proteins (NLM
                      Chemicals)},
      cin          = {AG Schultze / PRECISE / AG Aschenbrenner / AG Beyer},
      ddc          = {500},
      cid          = {I:(DE-2719)1013038 / I:(DE-2719)1013031 /
                      I:(DE-2719)5000082 / I:(DE-2719)1013035},
      pnm          = {354 - Disease Prevention and Healthy Aging (POF4-354) / 352
                      - Disease Mechanisms (POF4-352) / 351 - Brain Function
                      (POF4-351)},
      pid          = {G:(DE-HGF)POF4-354 / G:(DE-HGF)POF4-352 /
                      G:(DE-HGF)POF4-351},
      experiment   = {EXP:(DE-2719)PRECISE-20190321},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:40280932},
      pmc          = {pmc:PMC12032359},
      doi          = {10.1038/s41467-025-58907-y},
      url          = {https://pub.dzne.de/record/278067},
}