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000278072 0247_ $$2ISSN$$a1552-5279
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000278072 037__ $$aDZNE-2025-00563
000278072 041__ $$aEnglish
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000278072 1001_ $$aLiu, Xulin$$b0
000278072 245__ $$aSex differences in clinical phenotypes of behavioral variant frontotemporal dementia.
000278072 260__ $$aHoboken, NJ$$bWiley$$c2025
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000278072 520__ $$aHigher male prevalence in sporadic behavioral variant frontotemporal dementia (bvFTD) has been reported. We hypothesized differences in phenotypes between genetic and sporadic bvFTD females resulting in underdiagnosis of sporadic bvFTD females.We included genetic and sporadic bvFTD patients from two multicenter cohorts. We compared behavioral and cognitive symptoms, and gray matter volumes, between genetic and sporadic cases in each sex.Females with sporadic bvFTD showed worse compulsive behavior (p = 0.026) and language impairments (p = 0.024) compared to females with genetic bvFTD (n = 152). Genetic bvFTD females had smaller gray matter volumes than sporadic bvFTD females, particularly in the parietal lobe.Females with sporadic bvFTD exhibit a distinct clinical phenotype compared to females with genetic bvFTD. This difference may explain the discrepancy in prevalence between genetic and sporadic cases, as some females without genetic mutations may be misdiagnosed due to atypical bvFTD symptom presentation.Sex ratio is equal in genetic behavioral variant of frontotemporal dementia (bvFTD), whereas more males are present in sporadic bvFTD. Distinct neuropsychiatric phenotypes exist between sporadic and genetic bvFTD in females. Phenotype might explain the sex ratio difference between sporadic and genetic cases.
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000278072 650_7 $$2Other$$abehavioral variant frontotemporal dementia
000278072 650_7 $$2Other$$aclinical diagnosis
000278072 650_7 $$2Other$$adiversity
000278072 650_7 $$2Other$$asex difference
000278072 650_2 $$2MeSH$$aHumans
000278072 650_2 $$2MeSH$$aFrontotemporal Dementia: genetics
000278072 650_2 $$2MeSH$$aFrontotemporal Dementia: pathology
000278072 650_2 $$2MeSH$$aFrontotemporal Dementia: diagnostic imaging
000278072 650_2 $$2MeSH$$aFemale
000278072 650_2 $$2MeSH$$aMale
000278072 650_2 $$2MeSH$$aPhenotype
000278072 650_2 $$2MeSH$$aMiddle Aged
000278072 650_2 $$2MeSH$$aAged
000278072 650_2 $$2MeSH$$aMagnetic Resonance Imaging
000278072 650_2 $$2MeSH$$aGray Matter: pathology
000278072 650_2 $$2MeSH$$aGray Matter: diagnostic imaging
000278072 650_2 $$2MeSH$$aSex Characteristics
000278072 650_2 $$2MeSH$$aNeuropsychological Tests
000278072 650_2 $$2MeSH$$aCohort Studies
000278072 650_2 $$2MeSH$$aSex Factors
000278072 650_2 $$2MeSH$$aBrain: pathology
000278072 650_2 $$2MeSH$$aBrain: diagnostic imaging
000278072 7001_ $$ade Boer, Sterre C M$$b1
000278072 7001_ $$aCortez, Kasey$$b2
000278072 7001_ $$aPoos, Jackie M$$b3
000278072 7001_ $$aIllán-Gala, Ignacio$$b4
000278072 7001_ $$aHeuer, Hilary$$b5
000278072 7001_ $$aForsberg, Leah K$$b6
000278072 7001_ $$aCasaletto, Kaitlin$$b7
000278072 7001_ $$aMemel, Molly$$b8
000278072 7001_ $$aAppleby, Brian S$$b9
000278072 7001_ $$aBarmada, Sami$$b10
000278072 7001_ $$aBozoki, Andrea$$b11
000278072 7001_ $$aClark, David$$b12
000278072 7001_ $$aCobigo, Yann$$b13
000278072 7001_ $$aDarby, Ryan$$b14
000278072 7001_ $$aDickerson, Bradford C$$b15
000278072 7001_ $$aDomoto-Reilly, Kimiko$$b16
000278072 7001_ $$aGalasko, Douglas R$$b17
000278072 7001_ $$aGeschwind, Daniel H$$b18
000278072 7001_ $$aGhoshal, Nupur$$b19
000278072 7001_ $$aGraff-Radford, Neill R$$b20
000278072 7001_ $$aGrant, Ian M$$b21
000278072 7001_ $$aHsiung, Ging-Yuek Robin$$b22
000278072 7001_ $$aHonig, Lawrence S$$b23
000278072 7001_ $$aHuey, Edward D$$b24
000278072 7001_ $$aIrwin, David$$b25
000278072 7001_ $$aKantarci, Kejal$$b26
000278072 7001_ $$aLéger, Gabriel C$$b27
000278072 7001_ $$aLitvan, Irene$$b28
000278072 7001_ $$aMackenzie, Ian R$$b29
000278072 7001_ $$aMasdeu, Joseph C$$b30
000278072 7001_ $$aMendez, Mario F$$b31
000278072 7001_ $$aOnyike, Chiadi U$$b32
000278072 7001_ $$aPascual, Belen$$b33
000278072 7001_ $$aPressman, Peter$$b34
000278072 7001_ $$aBayram, Ece$$b35
000278072 7001_ $$aRamos, Eliana Marisa$$b36
000278072 7001_ $$aRoberson, Erik D$$b37
000278072 7001_ $$aRogalski, Emily$$b38
000278072 7001_ $$aBouzigues, Arabella$$b39
000278072 7001_ $$aRussell, Lucy L$$b40
000278072 7001_ $$aFoster, Phoebe H$$b41
000278072 7001_ $$aFerry-Bolder, Eve$$b42
000278072 7001_ $$aMasellis, Mario$$b43
000278072 7001_ $$avan Swieten, John$$b44
000278072 7001_ $$aJiskoot, Lize$$b45
000278072 7001_ $$aSeelaar, Harro$$b46
000278072 7001_ $$aSanchez-Valle, Raquel$$b47
000278072 7001_ $$aLaforce, Robert$$b48
000278072 7001_ $$aGraff, Caroline$$b49
000278072 7001_ $$aGalimberti, Daniela$$b50
000278072 7001_ $$aVandenberghe, Rik$$b51
000278072 7001_ $$ade Mendonça, Alexandre$$b52
000278072 7001_ $$aTiraboschi, Pietro$$b53
000278072 7001_ $$aSantana, Isabel$$b54
000278072 7001_ $$aGerhard, Alexander$$b55
000278072 7001_ $$0P:(DE-2719)2811659$$aLevin, Johannes$$b56$$udzne
000278072 7001_ $$aSorbi, Sandro$$b57
000278072 7001_ $$aOtto, Markus$$b58
000278072 7001_ $$aPasquier, Florence$$b59
000278072 7001_ $$aDucharme, Simon$$b60
000278072 7001_ $$aButler, Chris R$$b61
000278072 7001_ $$aBer, Isabelle Le$$b62
000278072 7001_ $$aFinger, Elizabeth$$b63
000278072 7001_ $$aRowe, James B$$b64
000278072 7001_ $$0P:(DE-2719)2811275$$aSynofzik, Matthis$$b65$$udzne
000278072 7001_ $$aMoreno, Fermin$$b66
000278072 7001_ $$aBorroni, Barbara$$b67
000278072 7001_ $$aBoeve, Brad F$$b68
000278072 7001_ $$aBoxer, Adam L$$b69
000278072 7001_ $$aRosen, Howie J$$b70
000278072 7001_ $$aPijnenburg, Yolande A L$$b71
000278072 7001_ $$aRohrer, Jonathan D$$b72
000278072 7001_ $$aTartaglia, Maria Carmela$$b73
000278072 7001_ $$aConsortium, ALLFTD$$b74
000278072 7001_ $$aConsortium, the GENFI$$b75$$eCollaboration Author
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