TY  - JOUR
AU  - Liu, Xulin
AU  - de Boer, Sterre C M
AU  - Cortez, Kasey
AU  - Poos, Jackie M
AU  - Illán-Gala, Ignacio
AU  - Heuer, Hilary
AU  - Forsberg, Leah K
AU  - Casaletto, Kaitlin
AU  - Memel, Molly
AU  - Appleby, Brian S
AU  - Barmada, Sami
AU  - Bozoki, Andrea
AU  - Clark, David
AU  - Cobigo, Yann
AU  - Darby, Ryan
AU  - Dickerson, Bradford C
AU  - Domoto-Reilly, Kimiko
AU  - Galasko, Douglas R
AU  - Geschwind, Daniel H
AU  - Ghoshal, Nupur
AU  - Graff-Radford, Neill R
AU  - Grant, Ian M
AU  - Hsiung, Ging-Yuek Robin
AU  - Honig, Lawrence S
AU  - Huey, Edward D
AU  - Irwin, David
AU  - Kantarci, Kejal
AU  - Léger, Gabriel C
AU  - Litvan, Irene
AU  - Mackenzie, Ian R
AU  - Masdeu, Joseph C
AU  - Mendez, Mario F
AU  - Onyike, Chiadi U
AU  - Pascual, Belen
AU  - Pressman, Peter
AU  - Bayram, Ece
AU  - Ramos, Eliana Marisa
AU  - Roberson, Erik D
AU  - Rogalski, Emily
AU  - Bouzigues, Arabella
AU  - Russell, Lucy L
AU  - Foster, Phoebe H
AU  - Ferry-Bolder, Eve
AU  - Masellis, Mario
AU  - van Swieten, John
AU  - Jiskoot, Lize
AU  - Seelaar, Harro
AU  - Sanchez-Valle, Raquel
AU  - Laforce, Robert
AU  - Graff, Caroline
AU  - Galimberti, Daniela
AU  - Vandenberghe, Rik
AU  - de Mendonça, Alexandre
AU  - Tiraboschi, Pietro
AU  - Santana, Isabel
AU  - Gerhard, Alexander
AU  - Levin, Johannes
AU  - Sorbi, Sandro
AU  - Otto, Markus
AU  - Pasquier, Florence
AU  - Ducharme, Simon
AU  - Butler, Chris R
AU  - Ber, Isabelle Le
AU  - Finger, Elizabeth
AU  - Rowe, James B
AU  - Synofzik, Matthis
AU  - Moreno, Fermin
AU  - Borroni, Barbara
AU  - Boeve, Brad F
AU  - Boxer, Adam L
AU  - Rosen, Howie J
AU  - Pijnenburg, Yolande A L
AU  - Rohrer, Jonathan D
AU  - Tartaglia, Maria Carmela
AU  - Consortium, ALLFTD
TI  - Sex differences in clinical phenotypes of behavioral variant frontotemporal dementia.
JO  - Alzheimer's and dementia
VL  - 21
IS  - 4
SN  - 1552-5260
CY  - Hoboken, NJ
PB  - Wiley
M1  - DZNE-2025-00563
SP  - e14608
PY  - 2025
AB  - Higher male prevalence in sporadic behavioral variant frontotemporal dementia (bvFTD) has been reported. We hypothesized differences in phenotypes between genetic and sporadic bvFTD females resulting in underdiagnosis of sporadic bvFTD females.We included genetic and sporadic bvFTD patients from two multicenter cohorts. We compared behavioral and cognitive symptoms, and gray matter volumes, between genetic and sporadic cases in each sex.Females with sporadic bvFTD showed worse compulsive behavior (p = 0.026) and language impairments (p = 0.024) compared to females with genetic bvFTD (n = 152). Genetic bvFTD females had smaller gray matter volumes than sporadic bvFTD females, particularly in the parietal lobe.Females with sporadic bvFTD exhibit a distinct clinical phenotype compared to females with genetic bvFTD. This difference may explain the discrepancy in prevalence between genetic and sporadic cases, as some females without genetic mutations may be misdiagnosed due to atypical bvFTD symptom presentation.Sex ratio is equal in genetic behavioral variant of frontotemporal dementia (bvFTD), whereas more males are present in sporadic bvFTD. Distinct neuropsychiatric phenotypes exist between sporadic and genetic bvFTD in females. Phenotype might explain the sex ratio difference between sporadic and genetic cases.
KW  - Humans
KW  - Frontotemporal Dementia: genetics
KW  - Frontotemporal Dementia: pathology
KW  - Frontotemporal Dementia: diagnostic imaging
KW  - Female
KW  - Male
KW  - Phenotype
KW  - Middle Aged
KW  - Aged
KW  - Magnetic Resonance Imaging
KW  - Gray Matter: pathology
KW  - Gray Matter: diagnostic imaging
KW  - Sex Characteristics
KW  - Neuropsychological Tests
KW  - Cohort Studies
KW  - Sex Factors
KW  - Brain: pathology
KW  - Brain: diagnostic imaging
KW  - behavioral variant frontotemporal dementia (Other)
KW  - clinical diagnosis (Other)
KW  - diversity (Other)
KW  - sex difference (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:40277074
C2  - pmc:PMC12022892
DO  - DOI:10.1002/alz.14608
UR  - https://pub.dzne.de/record/278072
ER  -