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@ARTICLE{Liu:278072,
      author       = {Liu, Xulin and de Boer, Sterre C M and Cortez, Kasey and
                      Poos, Jackie M and Illán-Gala, Ignacio and Heuer, Hilary
                      and Forsberg, Leah K and Casaletto, Kaitlin and Memel, Molly
                      and Appleby, Brian S and Barmada, Sami and Bozoki, Andrea
                      and Clark, David and Cobigo, Yann and Darby, Ryan and
                      Dickerson, Bradford C and Domoto-Reilly, Kimiko and Galasko,
                      Douglas R and Geschwind, Daniel H and Ghoshal, Nupur and
                      Graff-Radford, Neill R and Grant, Ian M and Hsiung,
                      Ging-Yuek Robin and Honig, Lawrence S and Huey, Edward D and
                      Irwin, David and Kantarci, Kejal and Léger, Gabriel C and
                      Litvan, Irene and Mackenzie, Ian R and Masdeu, Joseph C and
                      Mendez, Mario F and Onyike, Chiadi U and Pascual, Belen and
                      Pressman, Peter and Bayram, Ece and Ramos, Eliana Marisa and
                      Roberson, Erik D and Rogalski, Emily and Bouzigues, Arabella
                      and Russell, Lucy L and Foster, Phoebe H and Ferry-Bolder,
                      Eve and Masellis, Mario and van Swieten, John and Jiskoot,
                      Lize and Seelaar, Harro and Sanchez-Valle, Raquel and
                      Laforce, Robert and Graff, Caroline and Galimberti, Daniela
                      and Vandenberghe, Rik and de Mendonça, Alexandre and
                      Tiraboschi, Pietro and Santana, Isabel and Gerhard,
                      Alexander and Levin, Johannes and Sorbi, Sandro and Otto,
                      Markus and Pasquier, Florence and Ducharme, Simon and
                      Butler, Chris R and Ber, Isabelle Le and Finger, Elizabeth
                      and Rowe, James B and Synofzik, Matthis and Moreno, Fermin
                      and Borroni, Barbara and Boeve, Brad F and Boxer, Adam L and
                      Rosen, Howie J and Pijnenburg, Yolande A L and Rohrer,
                      Jonathan D and Tartaglia, Maria Carmela and Consortium,
                      ALLFTD},
      collaboration = {Consortium, the GENFI},
      title        = {{S}ex differences in clinical phenotypes of behavioral
                      variant frontotemporal dementia.},
      journal      = {Alzheimer's and dementia},
      volume       = {21},
      number       = {4},
      issn         = {1552-5260},
      address      = {Hoboken, NJ},
      publisher    = {Wiley},
      reportid     = {DZNE-2025-00563},
      pages        = {e14608},
      year         = {2025},
      abstract     = {Higher male prevalence in sporadic behavioral variant
                      frontotemporal dementia (bvFTD) has been reported. We
                      hypothesized differences in phenotypes between genetic and
                      sporadic bvFTD females resulting in underdiagnosis of
                      sporadic bvFTD females.We included genetic and sporadic
                      bvFTD patients from two multicenter cohorts. We compared
                      behavioral and cognitive symptoms, and gray matter volumes,
                      between genetic and sporadic cases in each sex.Females with
                      sporadic bvFTD showed worse compulsive behavior (p = 0.026)
                      and language impairments (p = 0.024) compared to females
                      with genetic bvFTD (n = 152). Genetic bvFTD females had
                      smaller gray matter volumes than sporadic bvFTD females,
                      particularly in the parietal lobe.Females with sporadic
                      bvFTD exhibit a distinct clinical phenotype compared to
                      females with genetic bvFTD. This difference may explain the
                      discrepancy in prevalence between genetic and sporadic
                      cases, as some females without genetic mutations may be
                      misdiagnosed due to atypical bvFTD symptom presentation.Sex
                      ratio is equal in genetic behavioral variant of
                      frontotemporal dementia (bvFTD), whereas more males are
                      present in sporadic bvFTD. Distinct neuropsychiatric
                      phenotypes exist between sporadic and genetic bvFTD in
                      females. Phenotype might explain the sex ratio difference
                      between sporadic and genetic cases.},
      keywords     = {Humans / Frontotemporal Dementia: genetics / Frontotemporal
                      Dementia: pathology / Frontotemporal Dementia: diagnostic
                      imaging / Female / Male / Phenotype / Middle Aged / Aged /
                      Magnetic Resonance Imaging / Gray Matter: pathology / Gray
                      Matter: diagnostic imaging / Sex Characteristics /
                      Neuropsychological Tests / Cohort Studies / Sex Factors /
                      Brain: pathology / Brain: diagnostic imaging / behavioral
                      variant frontotemporal dementia (Other) / clinical diagnosis
                      (Other) / diversity (Other) / sex difference (Other)},
      cin          = {AG Levin / Clinical Research (Munich) / AG Gasser},
      ddc          = {610},
      cid          = {I:(DE-2719)1111016 / I:(DE-2719)1111015 /
                      I:(DE-2719)1210000},
      pnm          = {353 - Clinical and Health Care Research (POF4-353)},
      pid          = {G:(DE-HGF)POF4-353},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:40277074},
      pmc          = {pmc:PMC12022892},
      doi          = {10.1002/alz.14608},
      url          = {https://pub.dzne.de/record/278072},
}