Home > Publications Database > Sex differences in clinical phenotypes of behavioral variant frontotemporal dementia. > print

001     278072
005     20250504001226.0
024 7 _ |a 10.1002/alz.14608
|2 doi
024 7 _ |a pmid:40277074
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024 7 _ |a pmc:PMC12022892
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024 7 _ |a 1552-5260
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024 7 _ |a 1552-5279
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024 7 _ |a altmetric:176730058
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037 _ _ |a DZNE-2025-00563
041 _ _ |a English
082 _ _ |a 610
100 1 _ |a Liu, Xulin
|b 0
245 _ _ |a Sex differences in clinical phenotypes of behavioral variant frontotemporal dementia.
260 _ _ |a Hoboken, NJ
|c 2025
|b Wiley
336 7 _ |a article
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336 7 _ |a ARTICLE
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336 7 _ |a Journal Article
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520 _ _ |a Higher male prevalence in sporadic behavioral variant frontotemporal dementia (bvFTD) has been reported. We hypothesized differences in phenotypes between genetic and sporadic bvFTD females resulting in underdiagnosis of sporadic bvFTD females.We included genetic and sporadic bvFTD patients from two multicenter cohorts. We compared behavioral and cognitive symptoms, and gray matter volumes, between genetic and sporadic cases in each sex.Females with sporadic bvFTD showed worse compulsive behavior (p = 0.026) and language impairments (p = 0.024) compared to females with genetic bvFTD (n = 152). Genetic bvFTD females had smaller gray matter volumes than sporadic bvFTD females, particularly in the parietal lobe.Females with sporadic bvFTD exhibit a distinct clinical phenotype compared to females with genetic bvFTD. This difference may explain the discrepancy in prevalence between genetic and sporadic cases, as some females without genetic mutations may be misdiagnosed due to atypical bvFTD symptom presentation.Sex ratio is equal in genetic behavioral variant of frontotemporal dementia (bvFTD), whereas more males are present in sporadic bvFTD. Distinct neuropsychiatric phenotypes exist between sporadic and genetic bvFTD in females. Phenotype might explain the sex ratio difference between sporadic and genetic cases.
536 _ _ |a 353 - Clinical and Health Care Research (POF4-353)
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588 _ _ |a Dataset connected to CrossRef, PubMed, , Journals: pub.dzne.de
650 _ 7 |a behavioral variant frontotemporal dementia
|2 Other
650 _ 7 |a clinical diagnosis
|2 Other
650 _ 7 |a diversity
|2 Other
650 _ 7 |a sex difference
|2 Other
650 _ 2 |a Humans
|2 MeSH
650 _ 2 |a Frontotemporal Dementia: genetics
|2 MeSH
650 _ 2 |a Frontotemporal Dementia: pathology
|2 MeSH
650 _ 2 |a Frontotemporal Dementia: diagnostic imaging
|2 MeSH
650 _ 2 |a Female
|2 MeSH
650 _ 2 |a Male
|2 MeSH
650 _ 2 |a Phenotype
|2 MeSH
650 _ 2 |a Middle Aged
|2 MeSH
650 _ 2 |a Aged
|2 MeSH
650 _ 2 |a Magnetic Resonance Imaging
|2 MeSH
650 _ 2 |a Gray Matter: pathology
|2 MeSH
650 _ 2 |a Gray Matter: diagnostic imaging
|2 MeSH
650 _ 2 |a Sex Characteristics
|2 MeSH
650 _ 2 |a Neuropsychological Tests
|2 MeSH
650 _ 2 |a Cohort Studies
|2 MeSH
650 _ 2 |a Sex Factors
|2 MeSH
650 _ 2 |a Brain: pathology
|2 MeSH
650 _ 2 |a Brain: diagnostic imaging
|2 MeSH
700 1 _ |a de Boer, Sterre C M
|b 1
700 1 _ |a Cortez, Kasey
|b 2
700 1 _ |a Poos, Jackie M
|b 3
700 1 _ |a Illán-Gala, Ignacio
|b 4
700 1 _ |a Heuer, Hilary
|b 5
700 1 _ |a Forsberg, Leah K
|b 6
700 1 _ |a Casaletto, Kaitlin
|b 7
700 1 _ |a Memel, Molly
|b 8
700 1 _ |a Appleby, Brian S
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700 1 _ |a Barmada, Sami
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700 1 _ |a Bozoki, Andrea
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700 1 _ |a Clark, David
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700 1 _ |a Cobigo, Yann
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700 1 _ |a Darby, Ryan
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700 1 _ |a Dickerson, Bradford C
|b 15
700 1 _ |a Domoto-Reilly, Kimiko
|b 16
700 1 _ |a Galasko, Douglas R
|b 17
700 1 _ |a Geschwind, Daniel H
|b 18
700 1 _ |a Ghoshal, Nupur
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700 1 _ |a Graff-Radford, Neill R
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700 1 _ |a Grant, Ian M
|b 21
700 1 _ |a Hsiung, Ging-Yuek Robin
|b 22
700 1 _ |a Honig, Lawrence S
|b 23
700 1 _ |a Huey, Edward D
|b 24
700 1 _ |a Irwin, David
|b 25
700 1 _ |a Kantarci, Kejal
|b 26
700 1 _ |a Léger, Gabriel C
|b 27
700 1 _ |a Litvan, Irene
|b 28
700 1 _ |a Mackenzie, Ian R
|b 29
700 1 _ |a Masdeu, Joseph C
|b 30
700 1 _ |a Mendez, Mario F
|b 31
700 1 _ |a Onyike, Chiadi U
|b 32
700 1 _ |a Pascual, Belen
|b 33
700 1 _ |a Pressman, Peter
|b 34
700 1 _ |a Bayram, Ece
|b 35
700 1 _ |a Ramos, Eliana Marisa
|b 36
700 1 _ |a Roberson, Erik D
|b 37
700 1 _ |a Rogalski, Emily
|b 38
700 1 _ |a Bouzigues, Arabella
|b 39
700 1 _ |a Russell, Lucy L
|b 40
700 1 _ |a Foster, Phoebe H
|b 41
700 1 _ |a Ferry-Bolder, Eve
|b 42
700 1 _ |a Masellis, Mario
|b 43
700 1 _ |a van Swieten, John
|b 44
700 1 _ |a Jiskoot, Lize
|b 45
700 1 _ |a Seelaar, Harro
|b 46
700 1 _ |a Sanchez-Valle, Raquel
|b 47
700 1 _ |a Laforce, Robert
|b 48
700 1 _ |a Graff, Caroline
|b 49
700 1 _ |a Galimberti, Daniela
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700 1 _ |a Vandenberghe, Rik
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700 1 _ |a de Mendonça, Alexandre
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700 1 _ |a Tiraboschi, Pietro
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700 1 _ |a Santana, Isabel
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700 1 _ |a Gerhard, Alexander
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700 1 _ |a Levin, Johannes
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700 1 _ |a Sorbi, Sandro
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700 1 _ |a Otto, Markus
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700 1 _ |a Pasquier, Florence
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700 1 _ |a Ducharme, Simon
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700 1 _ |a Butler, Chris R
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700 1 _ |a Ber, Isabelle Le
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700 1 _ |a Finger, Elizabeth
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700 1 _ |a Rowe, James B
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700 1 _ |a Synofzik, Matthis
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700 1 _ |a Moreno, Fermin
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700 1 _ |a Borroni, Barbara
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700 1 _ |a Boeve, Brad F
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700 1 _ |a Boxer, Adam L
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700 1 _ |a Rosen, Howie J
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700 1 _ |a Pijnenburg, Yolande A L
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700 1 _ |a Rohrer, Jonathan D
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700 1 _ |a Tartaglia, Maria Carmela
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700 1 _ |a Consortium, ALLFTD
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700 1 _ |a Consortium, the GENFI
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773 _ _ |a 10.1002/alz.14608
|g Vol. 21, no. 4, p. e14608
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