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000278074 1001_ $$aGernert, Jonathan A$$b0
000278074 245__ $$aCharacterization of Peripapillary Hyperreflective Ovoid Mass-like Structures in a Broad Spectrum of Neurologic Disorders.
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000278074 520__ $$aPeripapillary hyperreflective ovoid mass-like structures (PHOMSs) have been identified in ophthalmic and neurologic diseases. Because PHOMSs were found more frequently in these cohorts compared with healthy control participants, it is assumed that the presence of PHOMSs reflects a secondary disease marker of unknown significance. The extent to which disease-specific differences are reflected in PHOMSs has not yet been investigated sufficiently.Monocentric, retrospective study.We analyzed a large cohort of people with a broad spectrum of neurologic disorders, including neuroimmunologic diseases (NIDs; n = 237), epilepsy (n = 153), movement disorders (MDs; n = 44), intracranial hypertension (IH; n = 13), and inborn errors of metabolism (n = 90).We analyzed the prevalence, location, volume, and intensity of PHOMSs. Peripapillary hyperreflective ovoid mass-like structure volumes were correlated with demographic and other OCT parameters.Prevalence, location, volume, and intensity of PHOMSs.We identified PHOMSs in 7% of the analyzed eyes. Peripapillary hyperreflective ovoid mass-like structures were detected in all cohorts, and their location was predominantly nasal. The median volume of all PHOMSs was 0.06 mm3. However, the median PHOMS volume was increased in those with IH compared with those with NID (P = 0.009), epilepsy (P = 0.038), or MDs (P = 0.027). The PHOMS volume correlated positively with the opening of the Bruch membrane and correlated negatively with the age of the cohort after the exclusion of patients with IH. Overall, PHOMS intensity was comparable with that of the optic nerve.Because larger PHOMS volumes were found in individuals with IH, a mechanistic link to increased intracranial pressure can be assumed. It remains unclear whether this explanation also applies to individuals with other neurologic disorders with PHOMSs. Because PHOMSs have a relevant influence on OCT parameters, their presence also should be considered in nonophthalmic scientific studies in the future.Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.
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000278074 650_7 $$2Other$$aNeurologic disorders
000278074 650_7 $$2Other$$aOCT
000278074 650_7 $$2Other$$aPHOMS
000278074 650_2 $$2MeSH$$aHumans
000278074 650_2 $$2MeSH$$aRetrospective Studies
000278074 650_2 $$2MeSH$$aMale
000278074 650_2 $$2MeSH$$aFemale
000278074 650_2 $$2MeSH$$aAdult
000278074 650_2 $$2MeSH$$aTomography, Optical Coherence: methods
000278074 650_2 $$2MeSH$$aMiddle Aged
000278074 650_2 $$2MeSH$$aOptic Disk: pathology
000278074 650_2 $$2MeSH$$aNervous System Diseases: diagnosis
000278074 650_2 $$2MeSH$$aNervous System Diseases: complications
000278074 650_2 $$2MeSH$$aYoung Adult
000278074 650_2 $$2MeSH$$aAged
000278074 650_2 $$2MeSH$$aAdolescent
000278074 650_2 $$2MeSH$$aChild
000278074 7001_ $$aChristmann, Tara$$b1
000278074 7001_ $$aKaufmann, Elisabeth$$b2
000278074 7001_ $$aDelazer, Luisa$$b3
000278074 7001_ $$0P:(DE-2719)9002725$$aKirsch, Isabel$$b4$$udzne
000278074 7001_ $$0P:(DE-2719)2811659$$aLevin, Johannes$$b5$$udzne
000278074 7001_ $$aSchönecker, Sonja$$b6
000278074 7001_ $$0P:(DE-2719)9001214$$aFietzek, Urban$$b7$$udzne
000278074 7001_ $$aEulenburg, Peter Zu$$b8
000278074 7001_ $$aVelten, Theresa$$b9
000278074 7001_ $$aGripshi, Marina$$b10
000278074 7001_ $$aParhofer, Klaus G$$b11
000278074 7001_ $$aMaier, Esther M$$b12
000278074 7001_ $$aKümpfel, Tania$$b13
000278074 7001_ $$aLotz-Havla, Amelie S$$b14
000278074 7001_ $$aHavla, Joachim$$b15
000278074 773__ $$0PERI:(DE-600)2015287-5$$a10.1016/j.ophtha.2024.12.013$$gVol. 132, no. 5, p. 590 - 597$$n5$$p590 - 597$$tOphthalmology$$v132$$x0161-6420$$y2025
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