TY  - JOUR
AU  - Gernert, Jonathan A
AU  - Christmann, Tara
AU  - Kaufmann, Elisabeth
AU  - Delazer, Luisa
AU  - Kirsch, Isabel
AU  - Levin, Johannes
AU  - Schönecker, Sonja
AU  - Fietzek, Urban
AU  - Eulenburg, Peter Zu
AU  - Velten, Theresa
AU  - Gripshi, Marina
AU  - Parhofer, Klaus G
AU  - Maier, Esther M
AU  - Kümpfel, Tania
AU  - Lotz-Havla, Amelie S
AU  - Havla, Joachim
TI  - Characterization of Peripapillary Hyperreflective Ovoid Mass-like Structures in a Broad Spectrum of Neurologic Disorders.
JO  - Ophthalmology
VL  - 132
IS  - 5
SN  - 0161-6420
CY  - Amsterdam [u.a.]
PB  - Elsevier
M1  - DZNE-2025-00565
SP  - 590 - 597
PY  - 2025
AB  - Peripapillary hyperreflective ovoid mass-like structures (PHOMSs) have been identified in ophthalmic and neurologic diseases. Because PHOMSs were found more frequently in these cohorts compared with healthy control participants, it is assumed that the presence of PHOMSs reflects a secondary disease marker of unknown significance. The extent to which disease-specific differences are reflected in PHOMSs has not yet been investigated sufficiently.Monocentric, retrospective study.We analyzed a large cohort of people with a broad spectrum of neurologic disorders, including neuroimmunologic diseases (NIDs; n = 237), epilepsy (n = 153), movement disorders (MDs; n = 44), intracranial hypertension (IH; n = 13), and inborn errors of metabolism (n = 90).We analyzed the prevalence, location, volume, and intensity of PHOMSs. Peripapillary hyperreflective ovoid mass-like structure volumes were correlated with demographic and other OCT parameters.Prevalence, location, volume, and intensity of PHOMSs.We identified PHOMSs in 7
KW  - Humans
KW  - Retrospective Studies
KW  - Male
KW  - Female
KW  - Adult
KW  - Tomography, Optical Coherence: methods
KW  - Middle Aged
KW  - Optic Disk: pathology
KW  - Nervous System Diseases: diagnosis
KW  - Nervous System Diseases: complications
KW  - Young Adult
KW  - Aged
KW  - Adolescent
KW  - Child
KW  - Neurologic disorders (Other)
KW  - OCT (Other)
KW  - PHOMS (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:39675637
DO  - DOI:10.1016/j.ophtha.2024.12.013
UR  - https://pub.dzne.de/record/278074
ER  -