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@ARTICLE{Gernert:278074,
      author       = {Gernert, Jonathan A and Christmann, Tara and Kaufmann,
                      Elisabeth and Delazer, Luisa and Kirsch, Isabel and Levin,
                      Johannes and Schönecker, Sonja and Fietzek, Urban and
                      Eulenburg, Peter Zu and Velten, Theresa and Gripshi, Marina
                      and Parhofer, Klaus G and Maier, Esther M and Kümpfel,
                      Tania and Lotz-Havla, Amelie S and Havla, Joachim},
      title        = {{C}haracterization of {P}eripapillary {H}yperreflective
                      {O}void {M}ass-like {S}tructures in a {B}road {S}pectrum of
                      {N}eurologic {D}isorders.},
      journal      = {Ophthalmology},
      volume       = {132},
      number       = {5},
      issn         = {0161-6420},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier},
      reportid     = {DZNE-2025-00565},
      pages        = {590 - 597},
      year         = {2025},
      abstract     = {Peripapillary hyperreflective ovoid mass-like structures
                      (PHOMSs) have been identified in ophthalmic and neurologic
                      diseases. Because PHOMSs were found more frequently in these
                      cohorts compared with healthy control participants, it is
                      assumed that the presence of PHOMSs reflects a secondary
                      disease marker of unknown significance. The extent to which
                      disease-specific differences are reflected in PHOMSs has not
                      yet been investigated sufficiently.Monocentric,
                      retrospective study.We analyzed a large cohort of people
                      with a broad spectrum of neurologic disorders, including
                      neuroimmunologic diseases (NIDs; n = 237), epilepsy (n =
                      153), movement disorders (MDs; n = 44), intracranial
                      hypertension (IH; n = 13), and inborn errors of metabolism
                      (n = 90).We analyzed the prevalence, location, volume, and
                      intensity of PHOMSs. Peripapillary hyperreflective ovoid
                      mass-like structure volumes were correlated with demographic
                      and other OCT parameters.Prevalence, location, volume, and
                      intensity of PHOMSs.We identified PHOMSs in $7\%$ of the
                      analyzed eyes. Peripapillary hyperreflective ovoid mass-like
                      structures were detected in all cohorts, and their location
                      was predominantly nasal. The median volume of all PHOMSs was
                      0.06 mm3. However, the median PHOMS volume was increased in
                      those with IH compared with those with NID (P = 0.009),
                      epilepsy (P = 0.038), or MDs (P = 0.027). The PHOMS volume
                      correlated positively with the opening of the Bruch membrane
                      and correlated negatively with the age of the cohort after
                      the exclusion of patients with IH. Overall, PHOMS intensity
                      was comparable with that of the optic nerve.Because larger
                      PHOMS volumes were found in individuals with IH, a
                      mechanistic link to increased intracranial pressure can be
                      assumed. It remains unclear whether this explanation also
                      applies to individuals with other neurologic disorders with
                      PHOMSs. Because PHOMSs have a relevant influence on OCT
                      parameters, their presence also should be considered in
                      nonophthalmic scientific studies in the future.Proprietary
                      or commercial disclosure may be found in the Footnotes and
                      Disclosures at the end of this article.},
      keywords     = {Humans / Retrospective Studies / Male / Female / Adult /
                      Tomography, Optical Coherence: methods / Middle Aged / Optic
                      Disk: pathology / Nervous System Diseases: diagnosis /
                      Nervous System Diseases: complications / Young Adult / Aged
                      / Adolescent / Child / Neurologic disorders (Other) / OCT
                      (Other) / PHOMS (Other)},
      cin          = {AG Levin / Clinical Research (Munich)},
      ddc          = {610},
      cid          = {I:(DE-2719)1111016 / I:(DE-2719)1111015},
      pnm          = {353 - Clinical and Health Care Research (POF4-353)},
      pid          = {G:(DE-HGF)POF4-353},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:39675637},
      doi          = {10.1016/j.ophtha.2024.12.013},
      url          = {https://pub.dzne.de/record/278074},
}