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000278101 1001_ $$0P:(DE-2719)2000008$$aHeneka, Michael$$b0
000278101 245__ $$aNeuroinflammation in Alzheimer disease.
000278101 260__ $$aLondon$$bNature Publ. Group$$c2025
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000278101 520__ $$aIncreasing evidence points to a pivotal role of immune processes in the pathogenesis of Alzheimer disease, which is the most prevalent neurodegenerative and dementia-causing disease of our time. Multiple lines of information provided by experimental, epidemiological, neuropathological and genetic studies suggest a pathological role for innate and adaptive immune activation in this disease. Here, we review the cell types and pathological mechanisms involved in disease development as well as the influence of genetics and lifestyle factors. Given the decade-long preclinical stage of Alzheimer disease, these mechanisms and their interactions are driving forces behind the spread and progression of the disease. The identification of treatment opportunities will require a precise understanding of the cells and mechanisms involved as well as a clear definition of their temporal and topographical nature. We will also discuss new therapeutic strategies for targeting neuroinflammation, which are now entering the clinic and showing promise for patients.
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000278101 650_2 $$2MeSH$$aHumans
000278101 650_2 $$2MeSH$$aAlzheimer Disease: immunology
000278101 650_2 $$2MeSH$$aAlzheimer Disease: pathology
000278101 650_2 $$2MeSH$$aAlzheimer Disease: therapy
000278101 650_2 $$2MeSH$$aAnimals
000278101 650_2 $$2MeSH$$aNeuroinflammatory Diseases: immunology
000278101 650_2 $$2MeSH$$aNeuroinflammatory Diseases: pathology
000278101 650_2 $$2MeSH$$aInflammation: immunology
000278101 650_2 $$2MeSH$$aImmunity, Innate
000278101 7001_ $$avan der Flier, Wiesje M$$b1
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000278101 7001_ $$00000-0002-1036-1075$$aThal, Dietmar Rudolf$$b4
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000278101 7001_ $$00000-0002-4061-0837$$aTeunissen, Charlotte$$b7
000278101 7001_ $$aZetterberg, Henrik$$b8
000278101 7001_ $$aJacobs, Andreas H$$b9
000278101 7001_ $$00000-0002-6551-2002$$aEdison, Paul$$b10
000278101 7001_ $$0P:(DE-2719)2812825$$aRamirez, Alfredo$$b11$$udzne
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000278101 7001_ $$00000-0003-0829-7817$$aLambert, Jean-Charles$$b13
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000278101 7001_ $$00000-0002-9292-8521$$aSanchez-Mut, Jose Vicente$$b15
000278101 7001_ $$0P:(DE-2719)2000047$$aFischer, Andre$$b16
000278101 7001_ $$0P:(DE-2719)9002230$$aCastro-Gomez, Mario Sergio$$b17$$udzne
000278101 7001_ $$aStein, Thor D$$b18
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