TY  - JOUR
AU  - Heneka, Michael
AU  - van der Flier, Wiesje M
AU  - Jessen, Frank
AU  - Hoozemanns, Jeroen
AU  - Thal, Dietmar Rudolf
AU  - Boche, Delphine
AU  - Brosseron, Frederic
AU  - Teunissen, Charlotte
AU  - Zetterberg, Henrik
AU  - Jacobs, Andreas H
AU  - Edison, Paul
AU  - Ramirez, Alfredo
AU  - Cruchaga, Carlos
AU  - Lambert, Jean-Charles
AU  - Laza, Agustin Ruiz
AU  - Sanchez-Mut, Jose Vicente
AU  - Fischer, Andre
AU  - Castro-Gomez, Mario Sergio
AU  - Stein, Thor D
AU  - Kleineidam, Luca
AU  - Wagner, Michael
AU  - Neher, Jonas J
AU  - Cunningham, Colm
AU  - Singhrao, Sim K
AU  - Prinz, Marco
AU  - Glass, Christopher K
AU  - Schlachetzki, Johannes C M
AU  - Butovsky, Oleg
AU  - Kleemann, Kilian
AU  - De Jaeger, Philip L
AU  - Scheiblich, Hannah
AU  - Brown, Guy C
AU  - Landreth, Gary
AU  - Moutinho, Miguel
AU  - Grutzendler, Jaime
AU  - Gomez-Nicola, Diego
AU  - McManus, Róisín M
AU  - Andreasson, Katrin
AU  - Ising, Christina
AU  - Karabag, Deniz
AU  - Baker, Darren J
AU  - Liddelow, Shane A
AU  - Verkhratsky, Alexei
AU  - Tansey, Malu
AU  - Monsonego, Alon
AU  - Aigner, Ludwig
AU  - Dorothée, Guillaume
AU  - Nave, Klaus-Armin
AU  - Simons, Mikael
AU  - Constantin, Gabriela
AU  - Rosenzweig, Neta
AU  - Pascual, Alberto
AU  - Petzold, Gabor C
AU  - Kipnis, Jonathan
AU  - Venegas, Carmen
AU  - Colonna, Marco
AU  - Walter, Jochen
AU  - Tenner, Andrea J
AU  - O'Banion, M Kerry
AU  - Steinert, Joern R
AU  - Feinstein, Douglas L
AU  - Sastre, Magdalena
AU  - Bhaskar, Kiran
AU  - Hong, Soyon
AU  - Schafer, Dorothy P
AU  - Golde, Todd
AU  - Ransohoff, Richard M
AU  - Morgan, David
AU  - Breitner, John
AU  - Mancuso, Renzo
AU  - Riechers, Sean-Patrick
TI  - Neuroinflammation in Alzheimer disease.
JO  - Nature reviews / Immunology
VL  - 25
IS  - 5
SN  - 1474-1733
CY  - London
PB  - Nature Publ. Group
M1  - DZNE-2025-00587
SP  - 321 - 352
PY  - 2025
AB  - Increasing evidence points to a pivotal role of immune processes in the pathogenesis of Alzheimer disease, which is the most prevalent neurodegenerative and dementia-causing disease of our time. Multiple lines of information provided by experimental, epidemiological, neuropathological and genetic studies suggest a pathological role for innate and adaptive immune activation in this disease. Here, we review the cell types and pathological mechanisms involved in disease development as well as the influence of genetics and lifestyle factors. Given the decade-long preclinical stage of Alzheimer disease, these mechanisms and their interactions are driving forces behind the spread and progression of the disease. The identification of treatment opportunities will require a precise understanding of the cells and mechanisms involved as well as a clear definition of their temporal and topographical nature. We will also discuss new therapeutic strategies for targeting neuroinflammation, which are now entering the clinic and showing promise for patients.
KW  - Humans
KW  - Alzheimer Disease: immunology
KW  - Alzheimer Disease: pathology
KW  - Alzheimer Disease: therapy
KW  - Animals
KW  - Neuroinflammatory Diseases: immunology
KW  - Neuroinflammatory Diseases: pathology
KW  - Inflammation: immunology
KW  - Immunity, Innate
LB  - PUB:(DE-HGF)16
C6  - pmid:39653749
DO  - DOI:10.1038/s41577-024-01104-7
UR  - https://pub.dzne.de/record/278101
ER  -