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@ARTICLE{Heneka:278101,
      author       = {Heneka, Michael and van der Flier, Wiesje M and Jessen,
                      Frank and Hoozemanns, Jeroen and Thal, Dietmar Rudolf and
                      Boche, Delphine and Brosseron, Frederic and Teunissen,
                      Charlotte and Zetterberg, Henrik and Jacobs, Andreas H and
                      Edison, Paul and Ramirez, Alfredo and Cruchaga, Carlos and
                      Lambert, Jean-Charles and Laza, Agustin Ruiz and
                      Sanchez-Mut, Jose Vicente and Fischer, Andre and
                      Castro-Gomez, Mario Sergio and Stein, Thor D and Kleineidam,
                      Luca and Wagner, Michael and Neher, Jonas J and Cunningham,
                      Colm and Singhrao, Sim K and Prinz, Marco and Glass,
                      Christopher K and Schlachetzki, Johannes C M and Butovsky,
                      Oleg and Kleemann, Kilian and De Jaeger, Philip L and
                      Scheiblich, Hannah and Brown, Guy C and Landreth, Gary and
                      Moutinho, Miguel and Grutzendler, Jaime and Gomez-Nicola,
                      Diego and McManus, Róisín M and Andreasson, Katrin and
                      Ising, Christina and Karabag, Deniz and Baker, Darren J and
                      Liddelow, Shane A and Verkhratsky, Alexei and Tansey, Malu
                      and Monsonego, Alon and Aigner, Ludwig and Dorothée,
                      Guillaume and Nave, Klaus-Armin and Simons, Mikael and
                      Constantin, Gabriela and Rosenzweig, Neta and Pascual,
                      Alberto and Petzold, Gabor C and Kipnis, Jonathan and
                      Venegas, Carmen and Colonna, Marco and Walter, Jochen and
                      Tenner, Andrea J and O'Banion, M Kerry and Steinert, Joern R
                      and Feinstein, Douglas L and Sastre, Magdalena and Bhaskar,
                      Kiran and Hong, Soyon and Schafer, Dorothy P and Golde, Todd
                      and Ransohoff, Richard M and Morgan, David and Breitner,
                      John and Mancuso, Renzo and Riechers, Sean-Patrick},
      title        = {{N}euroinflammation in {A}lzheimer disease.},
      journal      = {Nature reviews / Immunology},
      volume       = {25},
      number       = {5},
      issn         = {1474-1733},
      address      = {London},
      publisher    = {Nature Publ. Group},
      reportid     = {DZNE-2025-00587},
      pages        = {321 - 352},
      year         = {2025},
      abstract     = {Increasing evidence points to a pivotal role of immune
                      processes in the pathogenesis of Alzheimer disease, which is
                      the most prevalent neurodegenerative and dementia-causing
                      disease of our time. Multiple lines of information provided
                      by experimental, epidemiological, neuropathological and
                      genetic studies suggest a pathological role for innate and
                      adaptive immune activation in this disease. Here, we review
                      the cell types and pathological mechanisms involved in
                      disease development as well as the influence of genetics and
                      lifestyle factors. Given the decade-long preclinical stage
                      of Alzheimer disease, these mechanisms and their
                      interactions are driving forces behind the spread and
                      progression of the disease. The identification of treatment
                      opportunities will require a precise understanding of the
                      cells and mechanisms involved as well as a clear definition
                      of their temporal and topographical nature. We will also
                      discuss new therapeutic strategies for targeting
                      neuroinflammation, which are now entering the clinic and
                      showing promise for patients.},
      subtyp        = {Review Article},
      keywords     = {Humans / Alzheimer Disease: immunology / Alzheimer Disease:
                      pathology / Alzheimer Disease: therapy / Animals /
                      Neuroinflammatory Diseases: immunology / Neuroinflammatory
                      Diseases: pathology / Inflammation: immunology / Immunity,
                      Innate},
      cin          = {AG Heneka / AG Fischer / AG Wagner / AG Neher (München) /
                      AG Petzold},
      ddc          = {570},
      cid          = {I:(DE-2719)1011303 / I:(DE-2719)1410002 /
                      I:(DE-2719)1011201 / I:(DE-2719)1110011 /
                      I:(DE-2719)1013020},
      pnm          = {353 - Clinical and Health Care Research (POF4-353) / 352 -
                      Disease Mechanisms (POF4-352)},
      pid          = {G:(DE-HGF)POF4-353 / G:(DE-HGF)POF4-352},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:39653749},
      doi          = {10.1038/s41577-024-01104-7},
      url          = {https://pub.dzne.de/record/278101},
}