Home > Publications Database > Neuroinflammation in Alzheimer disease. > print

001     278101
005     20250525001301.0
024 7 _ |a 10.1038/s41577-024-01104-7
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024 7 _ |a pmid:39653749
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024 7 _ |a 1474-1733
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024 7 _ |a 1474-1741
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037 _ _ |a DZNE-2025-00587
041 _ _ |a English
082 _ _ |a 570
100 1 _ |a Heneka, Michael
|0 P:(DE-2719)2000008
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245 _ _ |a Neuroinflammation in Alzheimer disease.
260 _ _ |a London
|c 2025
|b Nature Publ. Group
336 7 _ |a article
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336 7 _ |a Journal Article
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336 7 _ |a ARTICLE
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336 7 _ |a JOURNAL_ARTICLE
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336 7 _ |a Journal Article
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520 _ _ |a Increasing evidence points to a pivotal role of immune processes in the pathogenesis of Alzheimer disease, which is the most prevalent neurodegenerative and dementia-causing disease of our time. Multiple lines of information provided by experimental, epidemiological, neuropathological and genetic studies suggest a pathological role for innate and adaptive immune activation in this disease. Here, we review the cell types and pathological mechanisms involved in disease development as well as the influence of genetics and lifestyle factors. Given the decade-long preclinical stage of Alzheimer disease, these mechanisms and their interactions are driving forces behind the spread and progression of the disease. The identification of treatment opportunities will require a precise understanding of the cells and mechanisms involved as well as a clear definition of their temporal and topographical nature. We will also discuss new therapeutic strategies for targeting neuroinflammation, which are now entering the clinic and showing promise for patients.
536 _ _ |a 353 - Clinical and Health Care Research (POF4-353)
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536 _ _ |a 352 - Disease Mechanisms (POF4-352)
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650 _ 2 |a Humans
|2 MeSH
650 _ 2 |a Alzheimer Disease: immunology
|2 MeSH
650 _ 2 |a Alzheimer Disease: pathology
|2 MeSH
650 _ 2 |a Alzheimer Disease: therapy
|2 MeSH
650 _ 2 |a Animals
|2 MeSH
650 _ 2 |a Neuroinflammatory Diseases: immunology
|2 MeSH
650 _ 2 |a Neuroinflammatory Diseases: pathology
|2 MeSH
650 _ 2 |a Inflammation: immunology
|2 MeSH
650 _ 2 |a Immunity, Innate
|2 MeSH
700 1 _ |a van der Flier, Wiesje M
|b 1
700 1 _ |a Jessen, Frank
|0 P:(DE-2719)2000032
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700 1 _ |a Hoozemanns, Jeroen
|b 3
700 1 _ |a Thal, Dietmar Rudolf
|0 0000-0002-1036-1075
|b 4
700 1 _ |a Boche, Delphine
|0 0000-0002-5884-130X
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700 1 _ |a Brosseron, Frederic
|0 P:(DE-2719)2810593
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700 1 _ |a Teunissen, Charlotte
|0 0000-0002-4061-0837
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700 1 _ |a Zetterberg, Henrik
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700 1 _ |a Jacobs, Andreas H
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700 1 _ |a Edison, Paul
|0 0000-0002-6551-2002
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700 1 _ |a Ramirez, Alfredo
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700 1 _ |a Cruchaga, Carlos
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700 1 _ |a Lambert, Jean-Charles
|0 0000-0003-0829-7817
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700 1 _ |a Laza, Agustin Ruiz
|0 0000-0003-2633-2495
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700 1 _ |a Sanchez-Mut, Jose Vicente
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700 1 _ |a Fischer, Andre
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700 1 _ |a Castro-Gomez, Mario Sergio
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700 1 _ |a Stein, Thor D
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700 1 _ |a Kleineidam, Luca
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700 1 _ |a Wagner, Michael
|0 P:(DE-2719)2000057
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700 1 _ |a Neher, Jonas J
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700 1 _ |a Cunningham, Colm
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700 1 _ |a Singhrao, Sim K
|b 23
700 1 _ |a Prinz, Marco
|0 0000-0002-0349-1955
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700 1 _ |a Glass, Christopher K
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700 1 _ |a Schlachetzki, Johannes C M
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700 1 _ |a Butovsky, Oleg
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700 1 _ |a Kleemann, Kilian
|b 28
700 1 _ |a De Jaeger, Philip L
|0 0000-0002-8057-2505
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700 1 _ |a Scheiblich, Hannah
|0 P:(DE-2719)9000371
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700 1 _ |a Brown, Guy C
|0 0000-0002-3610-1730
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700 1 _ |a Landreth, Gary
|0 0000-0002-8808-424X
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700 1 _ |a Moutinho, Miguel
|0 0000-0003-0525-9145
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700 1 _ |a Grutzendler, Jaime
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700 1 _ |a Gomez-Nicola, Diego
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700 1 _ |a McManus, Róisín M
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700 1 _ |a Andreasson, Katrin
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700 1 _ |a Ising, Christina
|0 P:(DE-2719)2812463
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700 1 _ |a Karabag, Deniz
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700 1 _ |a Baker, Darren J
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700 1 _ |a Liddelow, Shane A
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700 1 _ |a Verkhratsky, Alexei
|0 0000-0003-2592-9898
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700 1 _ |a Tansey, Malu
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700 1 _ |a Monsonego, Alon
|0 0000-0002-4888-7865
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700 1 _ |a Aigner, Ludwig
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700 1 _ |a Dorothée, Guillaume
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700 1 _ |a Nave, Klaus-Armin
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700 1 _ |a Simons, Mikael
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700 1 _ |a Constantin, Gabriela
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700 1 _ |a Rosenzweig, Neta
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700 1 _ |a Pascual, Alberto
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700 1 _ |a Petzold, Gabor C
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700 1 _ |a Kipnis, Jonathan
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700 1 _ |a Venegas, Carmen
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700 1 _ |a Colonna, Marco
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700 1 _ |a Walter, Jochen
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700 1 _ |a Tenner, Andrea J
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700 1 _ |a O'Banion, M Kerry
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700 1 _ |a Steinert, Joern R
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700 1 _ |a Feinstein, Douglas L
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700 1 _ |a Sastre, Magdalena
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700 1 _ |a Bhaskar, Kiran
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700 1 _ |a Hong, Soyon
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700 1 _ |a Schafer, Dorothy P
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700 1 _ |a Golde, Todd
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700 1 _ |a Ransohoff, Richard M
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700 1 _ |a Morgan, David
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700 1 _ |a Breitner, John
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700 1 _ |a Mancuso, Renzo
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700 1 _ |a Riechers, Sean-Patrick
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773 _ _ |a 10.1038/s41577-024-01104-7
|g Vol. 25, no. 5, p. 321 - 352
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|t Nature reviews / Immunology
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