TY  - JOUR
AU  - Talevi, Valentina
AU  - Lee, Hang-mao
AU  - Liu, Dan
AU  - Beyer, Marc D
AU  - Salomoni, Paolo
AU  - Breteler, Monique M B
AU  - Aziz, N Ahmad
TI  - Age and Sex Effects on Blood Retrotransposable Element Expression Levels: Findings From the Population-Based Rhineland Study.
JO  - Aging cell
VL  - 24
IS  - 8
SN  - 1474-9718
CY  - Oxford [u.a.]
PB  - Wiley-Blackwell
M1  - DZNE-2025-00592
SP  - e70092
PY  - 2025
AB  - Retrotransposable elements (RTEs) have been implicated in the pathogenesis of several age-associated diseases. Although model systems indicate that age- and sex-dependent loss of heterochromatin increases RTE expression, data from large human studies are lacking. Here we assessed the expression levels of 795 blood RTE subfamilies in 2467 participants of the population-based Rhineland Study. We found that the expression of more than 98
KW  - aging (Other)
KW  - biomarkers (Other)
KW  - heterochromatin (Other)
KW  - immune response (Other)
KW  - population‐based study (Other)
KW  - retrotransposable elements (Other)
KW  - sex‐differences (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:40320676
DO  - DOI:10.1111/acel.70092
UR  - https://pub.dzne.de/record/278552
ER  -