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@ARTICLE{Talevi:278552,
      author       = {Talevi, Valentina and Lee, Hang-mao and Liu, Dan and Beyer,
                      Marc D and Salomoni, Paolo and Breteler, Monique M B and
                      Aziz, N Ahmad},
      title        = {{A}ge and {S}ex {E}ffects on {B}lood {R}etrotransposable
                      {E}lement {E}xpression {L}evels: {F}indings {F}rom the
                      {P}opulation-{B}ased {R}hineland {S}tudy.},
      journal      = {Aging cell},
      volume       = {24},
      number       = {8},
      issn         = {1474-9718},
      address      = {Oxford [u.a.]},
      publisher    = {Wiley-Blackwell},
      reportid     = {DZNE-2025-00592},
      pages        = {e70092},
      year         = {2025},
      abstract     = {Retrotransposable elements (RTEs) have been implicated in
                      the pathogenesis of several age-associated diseases.
                      Although model systems indicate that age- and sex-dependent
                      loss of heterochromatin increases RTE expression, data from
                      large human studies are lacking. Here we assessed the
                      expression levels of 795 blood RTE subfamilies in 2467
                      participants of the population-based Rhineland Study. We
                      found that the expression of more than $98\%$ of RTE
                      subfamilies increased with both chronological and biological
                      age. Moreover, the expression of heterochromatin regulators
                      involved in RTE silencing was negatively related to the
                      expression of 690 RTE subfamilies. Finally, we observed sex
                      differences in 42 RTE subfamilies, with higher expression in
                      men. The genes mapped to sex-related RTEs were enriched in
                      immune response-related pathways. Importantly, we validated
                      our key findings in an independent population-based cohort.
                      Our findings indicate that RTEs and their repressors are
                      markers of aging and that their dysregulation is linked to
                      inflammation, especially in men.},
      keywords     = {aging (Other) / biomarkers (Other) / heterochromatin
                      (Other) / immune response (Other) / population‐based study
                      (Other) / retrotransposable elements (Other) /
                      sex‐differences (Other)},
      cin          = {AG Aziz / AG Breteler / AG Liu / AG Beyer / AG Salomoni /
                      PRECISE},
      ddc          = {610},
      cid          = {I:(DE-2719)5000071 / I:(DE-2719)1012001 /
                      I:(DE-2719)1012009 / I:(DE-2719)1013035 / I:(DE-2719)1013032
                      / I:(DE-2719)1013031},
      pnm          = {354 - Disease Prevention and Healthy Aging (POF4-354) / 351
                      - Brain Function (POF4-351) / 352 - Disease Mechanisms
                      (POF4-352) / TRANSIT-ND - Tandem Repeats Associated with
                      Neurogenomic Somatic Instability and Neurodegeneration
                      (101041677)},
      pid          = {G:(DE-HGF)POF4-354 / G:(DE-HGF)POF4-351 /
                      G:(DE-HGF)POF4-352 / G:(EU-Grant)101041677},
      experiment   = {EXP:(DE-2719)Rhineland Study-20190321 /
                      EXP:(DE-2719)PRECISE-20190321},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:40320676},
      doi          = {10.1111/acel.70092},
      url          = {https://pub.dzne.de/record/278552},
}