TY  - JOUR
AU  - Lerche, Stefanie
AU  - Wurster, Isabel
AU  - Roeben, Benjamin
AU  - Zimmermann, Milan
AU  - Rossi, Marcello
AU  - Mammana, Angela
AU  - Baiardi, Simone
AU  - Hauser, Ann-Kathrin
AU  - Deuschle, Christian
AU  - Schulte, Claudia
AU  - Parchi, Piero
AU  - Brockmann, Kathrin
TI  - Differences in age-related distribution of CSF alpha-synuclein seeding and Alzheimer profiles between PD with and without GBA1 variants.
JO  - npj Parkinson's Disease
VL  - 11
IS  - 1
SN  - 2373-8057
CY  - [London]
PB  - Springer Nature
M1  - DZNE-2025-00594
SP  - 107
PY  - 2025
AB  - We studied the age- and genetic-related prevalence of CSF alpha-Synuclein seeding and Alzheimer profiles in 188 samples from PD participants without GBA1 variants (PDwildtype) and in 129 samples from PD participants with GBA1 variants (PDGBA1). While Alzheimer profiles increased with age in PDwildtype, it was sparse in PDGBA1. Alpha-Synuclein profiles remained stable with age in both cohorts. In PDwildtype, combined alpha-Synuclein/Alzheimer profiles were associated with earlier onset of cognitive impairment.
LB  - PUB:(DE-HGF)16
C6  - pmid:40324994
C2  - pmc:PMC12052968
DO  - DOI:10.1038/s41531-025-00978-1
UR  - https://pub.dzne.de/record/278561
ER  -