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@ARTICLE{Lerche:278561,
      author       = {Lerche, Stefanie and Wurster, Isabel and Roeben, Benjamin
                      and Zimmermann, Milan and Rossi, Marcello and Mammana,
                      Angela and Baiardi, Simone and Hauser, Ann-Kathrin and
                      Deuschle, Christian and Schulte, Claudia and Parchi, Piero
                      and Brockmann, Kathrin},
      title        = {{D}ifferences in age-related distribution of {CSF}
                      alpha-synuclein seeding and {A}lzheimer profiles between
                      {PD} with and without {GBA}1 variants.},
      journal      = {npj Parkinson's Disease},
      volume       = {11},
      number       = {1},
      issn         = {2373-8057},
      address      = {[London]},
      publisher    = {Springer Nature},
      reportid     = {DZNE-2025-00594},
      pages        = {107},
      year         = {2025},
      abstract     = {We studied the age- and genetic-related prevalence of CSF
                      alpha-Synuclein seeding and Alzheimer profiles in 188
                      samples from PD participants without GBA1 variants
                      (PDwildtype) and in 129 samples from PD participants with
                      GBA1 variants (PDGBA1). While Alzheimer profiles increased
                      with age in PDwildtype, it was sparse in PDGBA1.
                      Alpha-Synuclein profiles remained stable with age in both
                      cohorts. In PDwildtype, combined alpha-Synuclein/Alzheimer
                      profiles were associated with earlier onset of cognitive
                      impairment.},
      cin          = {AG Gasser / ICRU},
      ddc          = {610},
      cid          = {I:(DE-2719)1210000 / I:(DE-2719)1240005},
      pnm          = {353 - Clinical and Health Care Research (POF4-353) / 899 -
                      ohne Topic (POF4-899)},
      pid          = {G:(DE-HGF)POF4-353 / G:(DE-HGF)POF4-899},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:40324994},
      pmc          = {pmc:PMC12052968},
      doi          = {10.1038/s41531-025-00978-1},
      url          = {https://pub.dzne.de/record/278561},
}