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000278564 1001_ $$0P:(DE-2719)2810906$$aXie, Kan$$b0$$eFirst author$$udzne
000278564 245__ $$aIntermittent fasting boosts sexual behavior by limiting the central availability of tryptophan and serotonin.
000278564 260__ $$aAmsterdam [u.a.]$$bElsevier$$c2025
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000278564 520__ $$aAging affects reproductive capabilities in males through physiological and behavioral alterations, including endocrine changes and decreased libido. In this study, we investigated the influence of intermittent fasting (IF) on these aging-related declines, using male C57BL/6J mice. Our findings revealed that IF significantly preserved reproductive success in aged mice, not by improving traditional reproductive metrics such as sperm quality or endocrine functions but by enhancing mating behavior. This behavioral improvement was attributed to IF's ability to counter age-dependent increases in serotonergic inhibition, primarily through the decreased supply of the serotonin precursor tryptophan from the periphery to the brain. Our research underscores the potential of dietary interventions like IF in mitigating age-associated declines in male reproductive health and suggests a novel approach to managing conditions related to reduced sexual desire, highlighting the complex interplay between diet, metabolism, and reproductive behavior.
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000278564 650_7 $$2Other$$aaging
000278564 650_7 $$2Other$$aamino acid metabolism
000278564 650_7 $$2Other$$abrain
000278564 650_7 $$2Other$$afertility
000278564 650_7 $$2Other$$aintermittent fasting
000278564 650_7 $$2Other$$amale
000278564 650_7 $$2Other$$areproduction
000278564 650_7 $$2Other$$aserotonin
000278564 650_7 $$2Other$$asexual behavior
000278564 650_7 $$2Other$$atryptophan
000278564 650_7 $$08DUH1N11BX$$2NLM Chemicals$$aTryptophan
000278564 650_7 $$0333DO1RDJY$$2NLM Chemicals$$aSerotonin
000278564 650_2 $$2MeSH$$aAnimals
000278564 650_2 $$2MeSH$$aTryptophan: metabolism
000278564 650_2 $$2MeSH$$aSerotonin: metabolism
000278564 650_2 $$2MeSH$$aMale
000278564 650_2 $$2MeSH$$aFasting: physiology
000278564 650_2 $$2MeSH$$aMice, Inbred C57BL
000278564 650_2 $$2MeSH$$aSexual Behavior, Animal: physiology
000278564 650_2 $$2MeSH$$aMice
000278564 650_2 $$2MeSH$$aAging: physiology
000278564 650_2 $$2MeSH$$aFemale
000278564 650_2 $$2MeSH$$aIntermittent Fasting
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000278564 7001_ $$aWang, Chengfeng$$b1
000278564 7001_ $$0P:(DE-2719)2812562$$aScifo, Enzo$$b2$$udzne
000278564 7001_ $$0P:(DE-2719)2811584$$aPearson, Brandon$$b3
000278564 7001_ $$0P:(DE-2719)2431567$$aRyan, Devon$$b4
000278564 7001_ $$0P:(DE-2719)2810479$$aHenzel, Kristin$$b5
000278564 7001_ $$0P:(DE-2719)2811705$$aMarkert, Astrid$$b6
000278564 7001_ $$0P:(DE-2719)2812495$$aSchaaf, Kristina$$b7$$udzne
000278564 7001_ $$aMi, Xue$$b8
000278564 7001_ $$aTian, Xin$$b9
000278564 7001_ $$aJia, Jiajia$$b10
000278564 7001_ $$aWang, Meiqin$$b11
000278564 7001_ $$0P:(DE-2719)2810547$$aBonn, Stefan$$b12
000278564 7001_ $$0P:(DE-2719)2810990$$aSchölling, Manuel$$b13
000278564 7001_ $$0P:(DE-2719)2810422$$aMöhl, Christoph$$b14
000278564 7001_ $$0P:(DE-2719)2158358$$aBano, Daniele$$b15$$udzne
000278564 7001_ $$aZhou, Yu$$b16
000278564 7001_ $$0P:(DE-2719)2289209$$aEhninger, Dan$$b17$$eLast author$$udzne
000278564 773__ $$0PERI:(DE-600)2174469-5$$a10.1016/j.cmet.2025.03.001$$gVol. 37, no. 5, p. 1189 - 1205.e7$$n5$$p1189 - 1205.e7$$tCell metabolism$$v37$$x1550-4131$$y2025
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