% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{Xie:278564,
      author       = {Xie, Kan and Wang, Chengfeng and Scifo, Enzo and Pearson,
                      Brandon and Ryan, Devon and Henzel, Kristin and Markert,
                      Astrid and Schaaf, Kristina and Mi, Xue and Tian, Xin and
                      Jia, Jiajia and Wang, Meiqin and Bonn, Stefan and
                      Schölling, Manuel and Möhl, Christoph and Bano, Daniele
                      and Zhou, Yu and Ehninger, Dan},
      title        = {{I}ntermittent fasting boosts sexual behavior by limiting
                      the central availability of tryptophan and serotonin.},
      journal      = {Cell metabolism},
      volume       = {37},
      number       = {5},
      issn         = {1550-4131},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier},
      reportid     = {DZNE-2025-00597},
      pages        = {1189 - 1205.e7},
      year         = {2025},
      abstract     = {Aging affects reproductive capabilities in males through
                      physiological and behavioral alterations, including
                      endocrine changes and decreased libido. In this study, we
                      investigated the influence of intermittent fasting (IF) on
                      these aging-related declines, using male C57BL/6J mice. Our
                      findings revealed that IF significantly preserved
                      reproductive success in aged mice, not by improving
                      traditional reproductive metrics such as sperm quality or
                      endocrine functions but by enhancing mating behavior. This
                      behavioral improvement was attributed to IF's ability to
                      counter age-dependent increases in serotonergic inhibition,
                      primarily through the decreased supply of the serotonin
                      precursor tryptophan from the periphery to the brain. Our
                      research underscores the potential of dietary interventions
                      like IF in mitigating age-associated declines in male
                      reproductive health and suggests a novel approach to
                      managing conditions related to reduced sexual desire,
                      highlighting the complex interplay between diet, metabolism,
                      and reproductive behavior.},
      keywords     = {Animals / Tryptophan: metabolism / Serotonin: metabolism /
                      Male / Fasting: physiology / Mice, Inbred C57BL / Sexual
                      Behavior, Animal: physiology / Mice / Aging: physiology /
                      Female / Intermittent Fasting / aging (Other) / amino acid
                      metabolism (Other) / brain (Other) / fertility (Other) /
                      intermittent fasting (Other) / male (Other) / reproduction
                      (Other) / serotonin (Other) / sexual behavior (Other) /
                      tryptophan (Other) / Tryptophan (NLM Chemicals) / Serotonin
                      (NLM Chemicals)},
      cin          = {AG Ehninger / IDAF / AG Bano},
      ddc          = {570},
      cid          = {I:(DE-2719)1013005 / I:(DE-2719)1040200 /
                      I:(DE-2719)1013003},
      pnm          = {352 - Disease Mechanisms (POF4-352) / 351 - Brain Function
                      (POF4-351) / 899 - ohne Topic (POF4-899)},
      pid          = {G:(DE-HGF)POF4-352 / G:(DE-HGF)POF4-351 /
                      G:(DE-HGF)POF4-899},
      experiment   = {EXP:(DE-2719)IDAF-20190308},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:40157367},
      doi          = {10.1016/j.cmet.2025.03.001},
      url          = {https://pub.dzne.de/record/278564},
}