Home > Publications Database > Intermittent fasting boosts sexual behavior by limiting the central availability of tryptophan and serotonin. > print

001     278564
005     20250601001313.0
024 7 _ |a 10.1016/j.cmet.2025.03.001
|2 doi
024 7 _ |a pmid:40157367
|2 pmid
024 7 _ |a 1550-4131
|2 ISSN
024 7 _ |a 1932-7420
|2 ISSN
024 7 _ |a altmetric:175589037
|2 altmetric
037 _ _ |a DZNE-2025-00597
041 _ _ |a English
082 _ _ |a 570
100 1 _ |a Xie, Kan
|0 P:(DE-2719)2810906
|b 0
|e First author
|u dzne
245 _ _ |a Intermittent fasting boosts sexual behavior by limiting the central availability of tryptophan and serotonin.
260 _ _ |a Amsterdam [u.a.]
|c 2025
|b Elsevier
336 7 _ |a article
|2 DRIVER
336 7 _ |a Output Types/Journal article
|2 DataCite
336 7 _ |a Journal Article
|b journal
|m journal
|0 PUB:(DE-HGF)16
|s 1748421620_12512
|2 PUB:(DE-HGF)
336 7 _ |a ARTICLE
|2 BibTeX
336 7 _ |a JOURNAL_ARTICLE
|2 ORCID
336 7 _ |a Journal Article
|0 0
|2 EndNote
520 _ _ |a Aging affects reproductive capabilities in males through physiological and behavioral alterations, including endocrine changes and decreased libido. In this study, we investigated the influence of intermittent fasting (IF) on these aging-related declines, using male C57BL/6J mice. Our findings revealed that IF significantly preserved reproductive success in aged mice, not by improving traditional reproductive metrics such as sperm quality or endocrine functions but by enhancing mating behavior. This behavioral improvement was attributed to IF's ability to counter age-dependent increases in serotonergic inhibition, primarily through the decreased supply of the serotonin precursor tryptophan from the periphery to the brain. Our research underscores the potential of dietary interventions like IF in mitigating age-associated declines in male reproductive health and suggests a novel approach to managing conditions related to reduced sexual desire, highlighting the complex interplay between diet, metabolism, and reproductive behavior.
536 _ _ |a 352 - Disease Mechanisms (POF4-352)
|0 G:(DE-HGF)POF4-352
|c POF4-352
|f POF IV
|x 0
536 _ _ |a 351 - Brain Function (POF4-351)
|0 G:(DE-HGF)POF4-351
|c POF4-351
|f POF IV
|x 1
536 _ _ |a 899 - ohne Topic (POF4-899)
|0 G:(DE-HGF)POF4-899
|c POF4-899
|f POF IV
|x 2
588 _ _ |a Dataset connected to CrossRef, PubMed, , Journals: pub.dzne.de
650 _ 7 |a aging
|2 Other
650 _ 7 |a amino acid metabolism
|2 Other
650 _ 7 |a brain
|2 Other
650 _ 7 |a fertility
|2 Other
650 _ 7 |a intermittent fasting
|2 Other
650 _ 7 |a male
|2 Other
650 _ 7 |a reproduction
|2 Other
650 _ 7 |a serotonin
|2 Other
650 _ 7 |a sexual behavior
|2 Other
650 _ 7 |a tryptophan
|2 Other
650 _ 7 |a Tryptophan
|0 8DUH1N11BX
|2 NLM Chemicals
650 _ 7 |a Serotonin
|0 333DO1RDJY
|2 NLM Chemicals
650 _ 2 |a Animals
|2 MeSH
650 _ 2 |a Tryptophan: metabolism
|2 MeSH
650 _ 2 |a Serotonin: metabolism
|2 MeSH
650 _ 2 |a Male
|2 MeSH
650 _ 2 |a Fasting: physiology
|2 MeSH
650 _ 2 |a Mice, Inbred C57BL
|2 MeSH
650 _ 2 |a Sexual Behavior, Animal: physiology
|2 MeSH
650 _ 2 |a Mice
|2 MeSH
650 _ 2 |a Aging: physiology
|2 MeSH
650 _ 2 |a Female
|2 MeSH
650 _ 2 |a Intermittent Fasting
|2 MeSH
693 _ _ |0 EXP:(DE-2719)IDAF-20190308
|5 EXP:(DE-2719)IDAF-20190308
|e Image and Data Analysis Facility (CRFS-IDAF) / Bonn
|x 0
700 1 _ |a Wang, Chengfeng
|b 1
700 1 _ |a Scifo, Enzo
|0 P:(DE-2719)2812562
|b 2
|u dzne
700 1 _ |a Pearson, Brandon
|0 P:(DE-2719)2811584
|b 3
700 1 _ |a Ryan, Devon
|0 P:(DE-2719)2431567
|b 4
700 1 _ |a Henzel, Kristin
|0 P:(DE-2719)2810479
|b 5
700 1 _ |a Markert, Astrid
|0 P:(DE-2719)2811705
|b 6
700 1 _ |a Schaaf, Kristina
|0 P:(DE-2719)2812495
|b 7
|u dzne
700 1 _ |a Mi, Xue
|b 8
700 1 _ |a Tian, Xin
|b 9
700 1 _ |a Jia, Jiajia
|b 10
700 1 _ |a Wang, Meiqin
|b 11
700 1 _ |a Bonn, Stefan
|0 P:(DE-2719)2810547
|b 12
700 1 _ |a Schölling, Manuel
|0 P:(DE-2719)2810990
|b 13
700 1 _ |a Möhl, Christoph
|0 P:(DE-2719)2810422
|b 14
700 1 _ |a Bano, Daniele
|0 P:(DE-2719)2158358
|b 15
|u dzne
700 1 _ |a Zhou, Yu
|b 16
700 1 _ |a Ehninger, Dan
|0 P:(DE-2719)2289209
|b 17
|e Last author
|u dzne
773 _ _ |a 10.1016/j.cmet.2025.03.001
|g Vol. 37, no. 5, p. 1189 - 1205.e7
|0 PERI:(DE-600)2174469-5
|n 5
|p 1189 - 1205.e7
|t Cell metabolism
|v 37
|y 2025
|x 1550-4131
856 4 _ |u https://pub.dzne.de/record/278564/files/DZNE-2025-00597%20SUP.zip
856 4 _ |y OpenAccess
|u https://pub.dzne.de/record/278564/files/DZNE-2025-00597.pdf
856 4 _ |y OpenAccess
|x pdfa
|u https://pub.dzne.de/record/278564/files/DZNE-2025-00597.pdf?subformat=pdfa
909 C O |o oai:pub.dzne.de:278564
|p openaire
|p open_access
|p VDB
|p driver
|p dnbdelivery
910 1 _ |a Deutsches Zentrum für Neurodegenerative Erkrankungen
|0 I:(DE-588)1065079516
|k DZNE
|b 0
|6 P:(DE-2719)2810906
910 1 _ |a Deutsches Zentrum für Neurodegenerative Erkrankungen
|0 I:(DE-588)1065079516
|k DZNE
|b 2
|6 P:(DE-2719)2812562
910 1 _ |a Deutsches Zentrum für Neurodegenerative Erkrankungen
|0 I:(DE-588)1065079516
|k DZNE
|b 3
|6 P:(DE-2719)2811584
910 1 _ |a Deutsches Zentrum für Neurodegenerative Erkrankungen
|0 I:(DE-588)1065079516
|k DZNE
|b 4
|6 P:(DE-2719)2431567
910 1 _ |a Deutsches Zentrum für Neurodegenerative Erkrankungen
|0 I:(DE-588)1065079516
|k DZNE
|b 5
|6 P:(DE-2719)2810479
910 1 _ |a Deutsches Zentrum für Neurodegenerative Erkrankungen
|0 I:(DE-588)1065079516
|k DZNE
|b 6
|6 P:(DE-2719)2811705
910 1 _ |a Deutsches Zentrum für Neurodegenerative Erkrankungen
|0 I:(DE-588)1065079516
|k DZNE
|b 7
|6 P:(DE-2719)2812495
910 1 _ |a External Institute
|0 I:(DE-HGF)0
|k Extern
|b 12
|6 P:(DE-2719)2810547
910 1 _ |a Deutsches Zentrum für Neurodegenerative Erkrankungen
|0 I:(DE-588)1065079516
|k DZNE
|b 13
|6 P:(DE-2719)2810990
910 1 _ |a Deutsches Zentrum für Neurodegenerative Erkrankungen
|0 I:(DE-588)1065079516
|k DZNE
|b 14
|6 P:(DE-2719)2810422
910 1 _ |a Deutsches Zentrum für Neurodegenerative Erkrankungen
|0 I:(DE-588)1065079516
|k DZNE
|b 15
|6 P:(DE-2719)2158358
910 1 _ |a Deutsches Zentrum für Neurodegenerative Erkrankungen
|0 I:(DE-588)1065079516
|k DZNE
|b 17
|6 P:(DE-2719)2289209
913 1 _ |a DE-HGF
|b Gesundheit
|l Neurodegenerative Diseases
|1 G:(DE-HGF)POF4-350
|0 G:(DE-HGF)POF4-352
|3 G:(DE-HGF)POF4
|2 G:(DE-HGF)POF4-300
|4 G:(DE-HGF)POF
|v Disease Mechanisms
|x 0
913 1 _ |a DE-HGF
|b Gesundheit
|l Neurodegenerative Diseases
|1 G:(DE-HGF)POF4-350
|0 G:(DE-HGF)POF4-351
|3 G:(DE-HGF)POF4
|2 G:(DE-HGF)POF4-300
|4 G:(DE-HGF)POF
|v Brain Function
|x 1
913 1 _ |a DE-HGF
|b Programmungebundene Forschung
|l ohne Programm
|1 G:(DE-HGF)POF4-890
|0 G:(DE-HGF)POF4-899
|3 G:(DE-HGF)POF4
|2 G:(DE-HGF)POF4-800
|4 G:(DE-HGF)POF
|v ohne Topic
|x 2
914 1 _ |y 2025
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0200
|2 StatID
|b SCOPUS
|d 2024-12-28
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0300
|2 StatID
|b Medline
|d 2024-12-28
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)1050
|2 StatID
|b BIOSIS Previews
|d 2024-12-28
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)1190
|2 StatID
|b Biological Abstracts
|d 2024-12-28
915 _ _ |a Creative Commons Attribution CC BY 4.0
|0 LIC:(DE-HGF)CCBY4
|2 HGFVOC
915 _ _ |a JCR
|0 StatID:(DE-HGF)0100
|2 StatID
|b CELL METAB : 2022
|d 2024-12-28
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)1030
|2 StatID
|b Current Contents - Life Sciences
|d 2024-12-28
915 _ _ |a WoS
|0 StatID:(DE-HGF)0113
|2 StatID
|b Science Citation Index Expanded
|d 2024-12-28
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0150
|2 StatID
|b Web of Science Core Collection
|d 2024-12-28
915 _ _ |a OpenAccess
|0 StatID:(DE-HGF)0510
|2 StatID
915 _ _ |a IF >= 25
|0 StatID:(DE-HGF)9925
|2 StatID
|b CELL METAB : 2022
|d 2024-12-28
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0160
|2 StatID
|b Essential Science Indicators
|d 2024-12-28
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0199
|2 StatID
|b Clarivate Analytics Master Journal List
|d 2024-12-28
920 1 _ |0 I:(DE-2719)1013005
|k AG Ehninger
|l Translational Biogerontology
|x 0
920 1 _ |0 I:(DE-2719)1040200
|k IDAF
|l Image and Data Analysis (CRFS-IDAF)
|x 1
920 1 _ |0 I:(DE-2719)1013003
|k AG Bano
|l Aging and Neurodegeneration
|x 2
980 _ _ |a journal
980 _ _ |a VDB
980 _ _ |a UNRESTRICTED
980 _ _ |a I:(DE-2719)1013005
980 _ _ |a I:(DE-2719)1040200
980 _ _ |a I:(DE-2719)1013003
980 1 _ |a FullTexts

LibraryCollectionCLSMajorCLSMinorLanguageAuthor
Marc 21