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000278568 1001_ $$0P:(DE-2719)9002772$$aPolk, Sarah E$$b0$$eFirst author$$udzne
000278568 245__ $$aA scoping review of remote and unsupervised digital cognitive assessments in preclinical Alzheimer's disease.
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000278568 520__ $$aCharacterizing subtle cognitive changes in preclinical Alzheimer's disease (AD) is difficult using traditional neuropsychological assessments. Remote and unsupervised digital assessments can improve scalability, measurement reliability, and ecological validity, enabling the capture of subtle changes. We evaluate such tools for use in preclinical AD, or cognitively unimpaired individuals with abnormal levels of AD pathology. We screened 1904 reports for studies remotely assessing cognition in preclinical AD samples. Twenty-three tools were identified, and their usability, reliability, and validity, including construct and criterion validity based on in-person neuropsychological and Aβ/tau measures, was reported. We present a necessary update to a rapidly evolving field, following our previous review (Öhman et al., 2021) and address open questions of feasibility and reliability of remote testing in older adults. Future applications of such tools are discussed, including longitudinal monitoring of cognition, scalable case finding, and individualized prognostics in both clinical trials and healthcare contexts.
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000278568 7001_ $$aÖhman, Fredrik$$b1
000278568 7001_ $$aHassenstab, Jason$$b2
000278568 7001_ $$aKönig, Alexandra$$b3
000278568 7001_ $$aPapp, Kathryn V$$b4
000278568 7001_ $$aSchöll, Michael$$b5
000278568 7001_ $$0P:(DE-2719)2812972$$aBerron, David$$b6$$eLast author$$udzne
000278568 773__ $$0PERI:(DE-600)2925182-5$$a10.1038/s41746-025-01583-5$$gVol. 8, no. 1, p. 266$$n1$$p266$$tnpj digital medicine$$v8$$x2398-6352$$y2025
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