TY  - JOUR
AU  - Polk, Sarah E
AU  - Öhman, Fredrik
AU  - Hassenstab, Jason
AU  - König, Alexandra
AU  - Papp, Kathryn V
AU  - Schöll, Michael
AU  - Berron, David
TI  - A scoping review of remote and unsupervised digital cognitive assessments in preclinical Alzheimer's disease.
JO  - npj digital medicine
VL  - 8
IS  - 1
SN  - 2398-6352
CY  - [Basingstoke]
PB  - Macmillan Publishers Limited
M1  - DZNE-2025-00601
SP  - 266
PY  - 2025
AB  - Characterizing subtle cognitive changes in preclinical Alzheimer's disease (AD) is difficult using traditional neuropsychological assessments. Remote and unsupervised digital assessments can improve scalability, measurement reliability, and ecological validity, enabling the capture of subtle changes. We evaluate such tools for use in preclinical AD, or cognitively unimpaired individuals with abnormal levels of AD pathology. We screened 1904 reports for studies remotely assessing cognition in preclinical AD samples. Twenty-three tools were identified, and their usability, reliability, and validity, including construct and criterion validity based on in-person neuropsychological and Aβ/tau measures, was reported. We present a necessary update to a rapidly evolving field, following our previous review (Öhman et al., 2021) and address open questions of feasibility and reliability of remote testing in older adults. Future applications of such tools are discussed, including longitudinal monitoring of cognition, scalable case finding, and individualized prognostics in both clinical trials and healthcare contexts.
LB  - PUB:(DE-HGF)16
C6  - pmid:40348870
C2  - pmc:PMC12065824
DO  - DOI:10.1038/s41746-025-01583-5
UR  - https://pub.dzne.de/record/278568
ER  -