000278654 001__ 278654
000278654 005__ 20250601001324.0
000278654 0247_ $$2doi$$a10.1038/s41467-025-59338-5
000278654 0247_ $$2pmid$$apmid:40360474
000278654 0247_ $$2pmc$$apmc:PMC12075517
000278654 0247_ $$2altmetric$$aaltmetric:177061629
000278654 037__ $$aDZNE-2025-00610
000278654 041__ $$aEnglish
000278654 082__ $$a500
000278654 1001_ $$aAcharya, Dhiraj$$b0
000278654 245__ $$aTRIM23 mediates cGAS-induced autophagy in anti-HSV defense.
000278654 260__ $$a[London]$$bSpringer Nature$$c2025
000278654 3367_ $$2DRIVER$$aarticle
000278654 3367_ $$2DataCite$$aOutput Types/Journal article
000278654 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article$$bjournal$$mjournal$$s1748428534_8082
000278654 3367_ $$2BibTeX$$aARTICLE
000278654 3367_ $$2ORCID$$aJOURNAL_ARTICLE
000278654 3367_ $$00$$2EndNote$$aJournal Article
000278654 520__ $$aThe cGAS-STING pathway, well-known to elicit interferon (IFN) responses, is also a key inducer of autophagy upon virus infection or other stimuli. Whereas the mediators for cGAS-induced IFN responses are well characterized, much less is known about how cGAS elicits autophagy. Here, we report that TRIM23, a unique TRIM protein harboring both ubiquitin E3 ligase and GTPase activity, is crucial for cGAS-STING-dependent antiviral autophagy. Genetic ablation of TRIM23 impairs autophagic control of HSV-1 infection. HSV-1 infection or cGAS-STING stimulation induces TBK1-mediated TRIM23 phosphorylation at S39, which triggers TRIM23 autoubiquitination and GTPase activity and ultimately elicits autophagy. Fibroblasts from a patient with herpes simplex encephalitis heterozygous for a dominant-negative, kinase-inactivating TBK1 mutation fail to activate autophagy by TRIM23 and cGAS-STING. Our results thus identify the cGAS-STING-TBK1-TRIM23 axis as a key autophagy defense pathway and may stimulate new therapeutic interventions for viral or inflammatory diseases.
000278654 536__ $$0G:(DE-HGF)POF4-351$$a351 - Brain Function (POF4-351)$$cPOF4-351$$fPOF IV$$x0
000278654 588__ $$aDataset connected to CrossRef, PubMed, , Journals: pub.dzne.de
000278654 650_7 $$0EC 2.7.7.-$$2NLM Chemicals$$aNucleotidyltransferases
000278654 650_7 $$0EC 2.7.11.1$$2NLM Chemicals$$aProtein Serine-Threonine Kinases
000278654 650_7 $$2NLM Chemicals$$aMembrane Proteins
000278654 650_7 $$0EC 2.7.7.-$$2NLM Chemicals$$acGAS protein, human
000278654 650_7 $$0EC 2.7.11.1$$2NLM Chemicals$$aTBK1 protein, human
000278654 650_7 $$2NLM Chemicals$$aSTING1 protein, human
000278654 650_7 $$0EC 2.3.2.27$$2NLM Chemicals$$aUbiquitin-Protein Ligases
000278654 650_7 $$0EC 2.7.7.-$$2NLM Chemicals$$acGAS protein, mouse
000278654 650_2 $$2MeSH$$aAutophagy: immunology
000278654 650_2 $$2MeSH$$aHumans
000278654 650_2 $$2MeSH$$aNucleotidyltransferases: metabolism
000278654 650_2 $$2MeSH$$aNucleotidyltransferases: genetics
000278654 650_2 $$2MeSH$$aNucleotidyltransferases: immunology
000278654 650_2 $$2MeSH$$aHerpesvirus 1, Human: immunology
000278654 650_2 $$2MeSH$$aHerpesvirus 1, Human: physiology
000278654 650_2 $$2MeSH$$aProtein Serine-Threonine Kinases: metabolism
000278654 650_2 $$2MeSH$$aProtein Serine-Threonine Kinases: genetics
000278654 650_2 $$2MeSH$$aMembrane Proteins: metabolism
000278654 650_2 $$2MeSH$$aMembrane Proteins: genetics
000278654 650_2 $$2MeSH$$aAnimals
000278654 650_2 $$2MeSH$$aPhosphorylation
000278654 650_2 $$2MeSH$$aFibroblasts: metabolism
000278654 650_2 $$2MeSH$$aFibroblasts: virology
000278654 650_2 $$2MeSH$$aMice
000278654 650_2 $$2MeSH$$aUbiquitin-Protein Ligases: metabolism
000278654 650_2 $$2MeSH$$aUbiquitin-Protein Ligases: genetics
000278654 650_2 $$2MeSH$$aHerpes Simplex: immunology
000278654 650_2 $$2MeSH$$aHerpes Simplex: virology
000278654 650_2 $$2MeSH$$aHEK293 Cells
000278654 650_2 $$2MeSH$$aSignal Transduction
000278654 650_2 $$2MeSH$$aUbiquitination
000278654 7001_ $$00000-0003-1799-7604$$aSayyad, Zuberwasim$$b1
000278654 7001_ $$0P:(DE-2719)9003500$$aHoenigsperger, Helene$$b2$$udzne
000278654 7001_ $$0P:(DE-2719)9003503$$aHirschenberger, Maximilian$$b3$$udzne
000278654 7001_ $$aZurenski, Matthew$$b4
000278654 7001_ $$aBalakrishnan, Kannan$$b5
000278654 7001_ $$00000-0003-2968-180X$$aZhu, Junji$$b6
000278654 7001_ $$aGableske, Sebastian$$b7
000278654 7001_ $$00000-0003-0318-1794$$aKato, Jiro$$b8
000278654 7001_ $$0P:(DE-HGF)0$$aZhang, Shen-Ying$$b9
000278654 7001_ $$aCasanova, Jean-Laurent$$b10
000278654 7001_ $$aMoss, Joel$$b11
000278654 7001_ $$0P:(DE-2719)9003481$$aSparrer, Konstantin M J$$b12
000278654 7001_ $$00000-0002-2163-2598$$aGack, Michaela U$$b13
000278654 773__ $$0PERI:(DE-600)2553671-0$$a10.1038/s41467-025-59338-5$$gVol. 16, no. 1, p. 4418$$n1$$p4418$$tNature Communications$$v16$$x2041-1723$$y2025
000278654 8564_ $$uhttps://pub.dzne.de/record/278654/files/DZNE-2025-00610%20SUP.zip
000278654 8564_ $$uhttps://pub.dzne.de/record/278654/files/DZNE-2025-00610.pdf$$yOpenAccess
000278654 8564_ $$uhttps://pub.dzne.de/record/278654/files/DZNE-2025-00610.pdf?subformat=pdfa$$xpdfa$$yOpenAccess
000278654 909CO $$ooai:pub.dzne.de:278654$$pdnbdelivery$$pdriver$$pVDB$$popen_access$$popenaire
000278654 9101_ $$0I:(DE-HGF)0$$6P:(DE-2719)9003500$$aExternal Institute$$b2$$kExtern
000278654 9101_ $$0I:(DE-HGF)0$$6P:(DE-2719)9003503$$aExternal Institute$$b3$$kExtern
000278654 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)9003481$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b12$$kDZNE
000278654 9131_ $$0G:(DE-HGF)POF4-351$$1G:(DE-HGF)POF4-350$$2G:(DE-HGF)POF4-300$$3G:(DE-HGF)POF4$$4G:(DE-HGF)POF$$aDE-HGF$$bGesundheit$$lNeurodegenerative Diseases$$vBrain Function$$x0
000278654 9141_ $$y2025
000278654 915__ $$0StatID:(DE-HGF)0200$$2StatID$$aDBCoverage$$bSCOPUS$$d2025-01-02
000278654 915__ $$0StatID:(DE-HGF)0160$$2StatID$$aDBCoverage$$bEssential Science Indicators$$d2025-01-02
000278654 915__ $$0StatID:(DE-HGF)1050$$2StatID$$aDBCoverage$$bBIOSIS Previews$$d2025-01-02
000278654 915__ $$0StatID:(DE-HGF)1190$$2StatID$$aDBCoverage$$bBiological Abstracts$$d2025-01-02
000278654 915__ $$0StatID:(DE-HGF)0510$$2StatID$$aOpenAccess
000278654 915__ $$0StatID:(DE-HGF)1040$$2StatID$$aDBCoverage$$bZoological Record$$d2025-01-02
000278654 915__ $$0StatID:(DE-HGF)9915$$2StatID$$aIF >= 15$$bNAT COMMUN : 2022$$d2025-01-02
000278654 915__ $$0StatID:(DE-HGF)0100$$2StatID$$aJCR$$bNAT COMMUN : 2022$$d2025-01-02
000278654 915__ $$0LIC:(DE-HGF)CCBYNCND4$$2HGFVOC$$aCreative Commons Attribution-NonCommercial-NoDerivs CC BY-NC-ND 4.0
000278654 915__ $$0StatID:(DE-HGF)0501$$2StatID$$aDBCoverage$$bDOAJ Seal$$d2024-01-30T07:48:07Z
000278654 915__ $$0StatID:(DE-HGF)0500$$2StatID$$aDBCoverage$$bDOAJ$$d2024-01-30T07:48:07Z
000278654 915__ $$0StatID:(DE-HGF)1030$$2StatID$$aDBCoverage$$bCurrent Contents - Life Sciences$$d2025-01-02
000278654 915__ $$0StatID:(DE-HGF)0700$$2StatID$$aFees$$d2025-01-02
000278654 915__ $$0StatID:(DE-HGF)0150$$2StatID$$aDBCoverage$$bWeb of Science Core Collection$$d2025-01-02
000278654 915__ $$0StatID:(DE-HGF)0113$$2StatID$$aWoS$$bScience Citation Index Expanded$$d2025-01-02
000278654 915__ $$0StatID:(DE-HGF)0030$$2StatID$$aPeer Review$$bDOAJ : Peer review$$d2024-01-30T07:48:07Z
000278654 915__ $$0StatID:(DE-HGF)0561$$2StatID$$aArticle Processing Charges$$d2025-01-02
000278654 915__ $$0StatID:(DE-HGF)1060$$2StatID$$aDBCoverage$$bCurrent Contents - Agriculture, Biology and Environmental Sciences$$d2025-01-02
000278654 915__ $$0StatID:(DE-HGF)0300$$2StatID$$aDBCoverage$$bMedline$$d2025-01-02
000278654 915__ $$0StatID:(DE-HGF)1150$$2StatID$$aDBCoverage$$bCurrent Contents - Physical, Chemical and Earth Sciences$$d2025-01-02
000278654 915__ $$0StatID:(DE-HGF)0199$$2StatID$$aDBCoverage$$bClarivate Analytics Master Journal List$$d2025-01-02
000278654 9201_ $$0I:(DE-2719)1910003$$kAG Sparrer$$lNeurovirology and Neuroinflammation$$x0
000278654 980__ $$ajournal
000278654 980__ $$aVDB
000278654 980__ $$aUNRESTRICTED
000278654 980__ $$aI:(DE-2719)1910003
000278654 9801_ $$aFullTexts