%0 Journal Article
%A Nitsch, Louisa
%A Skowasch, Dirk
%A Courtin, Edouard
%A Duffau, Pierre
%A Otto, Carolin
%A Ruprecht, Klemens
%A Dambietz, Christine
%A Heming, Michael
%A Meyer Zu Hörste, Gerd
%A Byg, Keld-Erik
%A Kindler, Christine
%A Gutzwiller, Julia
%A Pretzsch, Roxanne
%A Pröbstel, Anne-Katrin
%A Weller, Johannes M
%A Zimmermann, Julian
%T Factors Associated With Relapse in Patients With Neurosarcoidosis.
%J Neurology
%V 104
%N 11
%@ 0028-3878
%C Philadelphia, Pa.
%I Wolters Kluwer
%M DZNE-2025-00620
%P e213705
%D 2025
%X Five to 10 percent of patients with sarcoidosis show involvement of the nervous system. Given the serious nature of neurosarcoidosis and the high risk of irreversible neurologic damage, rapid diagnosis, accurate prognostication, and individualized treatment are crucial. The aim of this study was to identify factors associated with relapses in neurosarcoidosis.In this multicenter retrospective cohort study, patients diagnosed with possible, probable, or definite neurosarcoidosis between January 1, 2010, and June 30, 2024, at 6 tertiary neuroimmunology centers across Europe were included. Patients were identified from the respective hospital-based databases by the participating centers. Clinical presentation, imaging results, CSF analysis, and immunosuppressive therapies were evaluated. Predictors of relapse, defined as clinical relapse or progression, or new MRI lesions on follow-up ≥2 months after initial manifestation, were analyzed with log-rank tests and Cox regression models, and therapeutic strategies in clinical practice were assessed. The association between identified risk factors (RFs) and therapeutic strategies was explored.A total of 174 patients with neurosarcoidosis were included with a median follow-up of 24 months (interquartile range 12-48.8). The mean age was 48.1 years, and 57.5
%K Humans
%K Sarcoidosis: cerebrospinal fluid
%K Sarcoidosis: diagnostic imaging
%K Sarcoidosis: epidemiology
%K Sarcoidosis: drug therapy
%K Female
%K Male
%K Middle Aged
%K Central Nervous System Diseases: cerebrospinal fluid
%K Central Nervous System Diseases: diagnostic imaging
%K Central Nervous System Diseases: epidemiology
%K Central Nervous System Diseases: drug therapy
%K Central Nervous System Diseases: diagnosis
%K Adult
%K Retrospective Studies
%K Recurrence
%K Risk Factors
%K Magnetic Resonance Imaging
%K Cohort Studies
%K Disease Progression
%K Immunosuppressive Agents: therapeutic use
%K Immunosuppressive Agents (NLM Chemicals)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:40373242
%R 10.1212/WNL.0000000000213705
%U https://pub.dzne.de/record/278784