TY  - JOUR
AU  - Nitsch, Louisa
AU  - Skowasch, Dirk
AU  - Courtin, Edouard
AU  - Duffau, Pierre
AU  - Otto, Carolin
AU  - Ruprecht, Klemens
AU  - Dambietz, Christine
AU  - Heming, Michael
AU  - Meyer Zu Hörste, Gerd
AU  - Byg, Keld-Erik
AU  - Kindler, Christine
AU  - Gutzwiller, Julia
AU  - Pretzsch, Roxanne
AU  - Pröbstel, Anne-Katrin
AU  - Weller, Johannes M
AU  - Zimmermann, Julian
TI  - Factors Associated With Relapse in Patients With Neurosarcoidosis.
JO  - Neurology
VL  - 104
IS  - 11
SN  - 0028-3878
CY  - Philadelphia, Pa.
PB  - Wolters Kluwer
M1  - DZNE-2025-00620
SP  - e213705
PY  - 2025
AB  - Five to 10 percent of patients with sarcoidosis show involvement of the nervous system. Given the serious nature of neurosarcoidosis and the high risk of irreversible neurologic damage, rapid diagnosis, accurate prognostication, and individualized treatment are crucial. The aim of this study was to identify factors associated with relapses in neurosarcoidosis.In this multicenter retrospective cohort study, patients diagnosed with possible, probable, or definite neurosarcoidosis between January 1, 2010, and June 30, 2024, at 6 tertiary neuroimmunology centers across Europe were included. Patients were identified from the respective hospital-based databases by the participating centers. Clinical presentation, imaging results, CSF analysis, and immunosuppressive therapies were evaluated. Predictors of relapse, defined as clinical relapse or progression, or new MRI lesions on follow-up ≥2 months after initial manifestation, were analyzed with log-rank tests and Cox regression models, and therapeutic strategies in clinical practice were assessed. The association between identified risk factors (RFs) and therapeutic strategies was explored.A total of 174 patients with neurosarcoidosis were included with a median follow-up of 24 months (interquartile range 12-48.8). The mean age was 48.1 years, and 57.5
KW  - Humans
KW  - Sarcoidosis: cerebrospinal fluid
KW  - Sarcoidosis: diagnostic imaging
KW  - Sarcoidosis: epidemiology
KW  - Sarcoidosis: drug therapy
KW  - Female
KW  - Male
KW  - Middle Aged
KW  - Central Nervous System Diseases: cerebrospinal fluid
KW  - Central Nervous System Diseases: diagnostic imaging
KW  - Central Nervous System Diseases: epidemiology
KW  - Central Nervous System Diseases: drug therapy
KW  - Central Nervous System Diseases: diagnosis
KW  - Adult
KW  - Retrospective Studies
KW  - Recurrence
KW  - Risk Factors
KW  - Magnetic Resonance Imaging
KW  - Cohort Studies
KW  - Disease Progression
KW  - Immunosuppressive Agents: therapeutic use
KW  - Immunosuppressive Agents (NLM Chemicals)
LB  - PUB:(DE-HGF)16
C6  - pmid:40373242
DO  - DOI:10.1212/WNL.0000000000213705
UR  - https://pub.dzne.de/record/278784
ER  -