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000278785 037__ $$aDZNE-2025-00621
000278785 041__ $$aEnglish
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000278785 1001_ $$aMüller, Julia$$b0
000278785 245__ $$aThe Impact of Loneliness on Late-Life Depression and Anxiety During the COVID-19 Pandemic.
000278785 260__ $$a[Amsterdam]$$bElsevier$$c2025
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000278785 520__ $$aThis study investigates the association of loneliness during the COVID-19 pandemic and the course of depressive, anxiety and sleep symptoms after psychological treatment in older adults.During the first wave of the pandemic in 2020, we assessed additional, original data of 132 participants aged ≥60 years who had completed psychological treatment for late-life depression (LLD) in the context of a multicenter, randomized controlled trial (CBT-late). We measured loneliness using the UCLA Loneliness Scale. Depression, anxiety and sleep symptoms were assessed using the Geriatric Depression Scale (GDS), Geriatric Anxiety Inventory (GAI), and Insomnia Severity Index (ISI).Participants with higher loneliness scores (n = 44) experienced a significant worsening of depressive and anxiety symptoms during the pandemic (estimated marginal mean difference (emmd) of change in GDS between post-treatment and COVID-19 visit: GDSemmd= -4.61, [95% CI: -6.97 to -2.26], GAIemmd= -2.21, [95% CI: -3.76 to -0.65]), while those with low to moderate loneliness (n = 72) maintained stable mild symptoms (GDSemmd= -1.39, [95% CI: -3.00 to 0.22], GAIemmd= -0.49, [95% CI: -1.69 to 0.72]). All patients reported increased sleep disturbances during the pandemic regardless of loneliness, while remaining in the range for sub-threshold insomnia.Our results suggest an association of significant loneliness during the COVID-19 pandemic and a clinically relevant worsening of depressive and anxiety symptoms in older adults. Loneliness assessments and interventions may be incorporated into treatments for LLD, particularly during pandemics or other crises.
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000278785 650_7 $$2Other$$aCBT-late
000278785 650_7 $$2Other$$aCOVID-19 pandemic
000278785 650_7 $$2Other$$aLate-life depression
000278785 650_7 $$2Other$$aloneliness
000278785 650_7 $$2Other$$aolder age
000278785 650_7 $$2Other$$apsychological treatment
000278785 650_2 $$2MeSH$$aHumans
000278785 650_2 $$2MeSH$$aLoneliness: psychology
000278785 650_2 $$2MeSH$$aCOVID-19: psychology
000278785 650_2 $$2MeSH$$aAged
000278785 650_2 $$2MeSH$$aMale
000278785 650_2 $$2MeSH$$aFemale
000278785 650_2 $$2MeSH$$aAnxiety: psychology
000278785 650_2 $$2MeSH$$aAnxiety: therapy
000278785 650_2 $$2MeSH$$aAnxiety: epidemiology
000278785 650_2 $$2MeSH$$aDepression: psychology
000278785 650_2 $$2MeSH$$aDepression: therapy
000278785 650_2 $$2MeSH$$aDepression: epidemiology
000278785 650_2 $$2MeSH$$aMiddle Aged
000278785 650_2 $$2MeSH$$aAged, 80 and over
000278785 650_2 $$2MeSH$$aSARS-CoV-2
000278785 650_2 $$2MeSH$$aSleep Initiation and Maintenance Disorders: psychology
000278785 7001_ $$aElsaesser, Moritz$$b1
000278785 7001_ $$aBerger, Ruben$$b2
000278785 7001_ $$aMüller, Wiebke$$b3
000278785 7001_ $$aHellmich, Martin$$b4
000278785 7001_ $$aZehender, Nadine$$b5
000278785 7001_ $$aRiedel-Heller, Steffi$$b6
000278785 7001_ $$aBewernick, Bettina H$$b7
000278785 7001_ $$0P:(DE-2719)2000057$$aWagner, Michael$$b8$$udzne
000278785 7001_ $$aFrölich, Lutz$$b9
000278785 7001_ $$0P:(DE-2719)2811024$$aPeters, Oliver$$b10
000278785 7001_ $$aDomschke, Katharina$$b11
000278785 7001_ $$0P:(DE-2719)2000032$$aJessen, Frank$$b12
000278785 7001_ $$aHautzinger, Martin$$b13
000278785 7001_ $$aDafsari, Forugh S$$b14
000278785 7001_ $$aSchramm, Elisabeth$$b15
000278785 773__ $$0PERI:(DE-600)1474415-6$$a10.1016/j.jagp.2025.01.003$$gVol. 33, no. 7, p. 717 - 729$$n7$$p717 - 729$$tAmerican journal of geriatric psychiatry$$v33$$x1064-7481$$y2025
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