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@ARTICLE{Mller:278785,
      author       = {Müller, Julia and Elsaesser, Moritz and Berger, Ruben and
                      Müller, Wiebke and Hellmich, Martin and Zehender, Nadine
                      and Riedel-Heller, Steffi and Bewernick, Bettina H and
                      Wagner, Michael and Frölich, Lutz and Peters, Oliver and
                      Domschke, Katharina and Jessen, Frank and Hautzinger, Martin
                      and Dafsari, Forugh S and Schramm, Elisabeth},
      title        = {{T}he {I}mpact of {L}oneliness on {L}ate-{L}ife
                      {D}epression and {A}nxiety {D}uring the {COVID}-19
                      {P}andemic.},
      journal      = {American journal of geriatric psychiatry},
      volume       = {33},
      number       = {7},
      issn         = {1064-7481},
      address      = {[Amsterdam]},
      publisher    = {Elsevier},
      reportid     = {DZNE-2025-00621},
      pages        = {717 - 729},
      year         = {2025},
      abstract     = {This study investigates the association of loneliness
                      during the COVID-19 pandemic and the course of depressive,
                      anxiety and sleep symptoms after psychological treatment in
                      older adults.During the first wave of the pandemic in 2020,
                      we assessed additional, original data of 132 participants
                      aged ≥60 years who had completed psychological treatment
                      for late-life depression (LLD) in the context of a
                      multicenter, randomized controlled trial (CBT-late). We
                      measured loneliness using the UCLA Loneliness Scale.
                      Depression, anxiety and sleep symptoms were assessed using
                      the Geriatric Depression Scale (GDS), Geriatric Anxiety
                      Inventory (GAI), and Insomnia Severity Index
                      (ISI).Participants with higher loneliness scores (n = 44)
                      experienced a significant worsening of depressive and
                      anxiety symptoms during the pandemic (estimated marginal
                      mean difference (emmd) of change in GDS between
                      post-treatment and COVID-19 visit: GDSemmd= -4.61, $[95\%$
                      CI: -6.97 to -2.26], GAIemmd= -2.21, $[95\%$ CI: -3.76 to
                      -0.65]), while those with low to moderate loneliness (n =
                      72) maintained stable mild symptoms (GDSemmd= -1.39, $[95\%$
                      CI: -3.00 to 0.22], GAIemmd= -0.49, $[95\%$ CI: -1.69 to
                      0.72]). All patients reported increased sleep disturbances
                      during the pandemic regardless of loneliness, while
                      remaining in the range for sub-threshold insomnia.Our
                      results suggest an association of significant loneliness
                      during the COVID-19 pandemic and a clinically relevant
                      worsening of depressive and anxiety symptoms in older
                      adults. Loneliness assessments and interventions may be
                      incorporated into treatments for LLD, particularly during
                      pandemics or other crises.},
      keywords     = {Humans / Loneliness: psychology / COVID-19: psychology /
                      Aged / Male / Female / Anxiety: psychology / Anxiety:
                      therapy / Anxiety: epidemiology / Depression: psychology /
                      Depression: therapy / Depression: epidemiology / Middle Aged
                      / Aged, 80 and over / SARS-CoV-2 / Sleep Initiation and
                      Maintenance Disorders: psychology / CBT-late (Other) /
                      COVID-19 pandemic (Other) / Late-life depression (Other) /
                      loneliness (Other) / older age (Other) / psychological
                      treatment (Other)},
      cin          = {AG Peters / AG Jessen},
      ddc          = {610},
      cid          = {I:(DE-2719)5000000 / I:(DE-2719)1011102},
      pnm          = {353 - Clinical and Health Care Research (POF4-353)},
      pid          = {G:(DE-HGF)POF4-353},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:39884877},
      doi          = {10.1016/j.jagp.2025.01.003},
      url          = {https://pub.dzne.de/record/278785},
}