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@ARTICLE{Purrer:278790,
      author       = {Purrer, Veronika and Chand, Tara and Pohl, Emily and
                      Weiland, Hannah and Borger, Valeri and Schmeel, Carsten and
                      Boecker, Henning and Wüllner, Ullrich},
      title        = {{Q}uantitative and qualitative tremor evaluation after
                      {MR}-guided focused ultrasound thalamotomy.},
      journal      = {Frontiers in neurology},
      volume       = {16},
      issn         = {1664-2295},
      address      = {Lausanne},
      publisher    = {Frontiers Research Foundation},
      reportid     = {DZNE-2025-00626},
      pages        = {1594382},
      year         = {2025},
      abstract     = {Tremor syndromes are common neurological disorders, usually
                      distinguished by clinical examination. Ordinal rating scales
                      are widely used to rate tremor severity but are limited by
                      subjective observation, interrater reliability, ceiling
                      effects and lack of knowledge about sensitivity to change
                      emphasizing the relevance of quantitative methods.To assess
                      tremor characteristics in essential tremor (ET) and
                      Parkinson's disease tremor (PT) quantitatively, we used a
                      wearable triaxial accelerometer in comparison to a common
                      clinical rating scale. Furthermore, different activation
                      conditions and changes after treatment with MR-guided
                      focused ultrasound (MRgFUS) were examined concomitantly.
                      Patients with disabling, medication-refractory ET (n = 35)
                      or PT (n = 21) undergoing unilateral MRgFUS thalamotomy were
                      assessed before, 1, 6 and 12 months after MRgFUS treatment.
                      Clinical assessments included the Clinical Rating Scale for
                      Tremor (CRST) and accelerometric recordings at rest, posture
                      and kinetic movement. Peak frequencies (fp), frequency width
                      at half maximum (FWHM), tremor stability index (TSI), and
                      half-width power (HWP) were extracted from the power
                      spectrum of acceleration and compared to the CRST.We
                      observed moderate to strong correlations between CRST
                      subscores and log-transformed HWP, whereas significant
                      correlations were only evident in ET when groups were
                      evaluated separately. Fp, FWHM and TSI showed no differences
                      between groups and conditions. Further, repeated
                      measurements after MRgFUS treatment revealed significant
                      changes of tremor severity in both, clinical rating and
                      accelerometric recordings.Tremor assessment using
                      accelerometric recordings provided a fast and investigator
                      independent method for tremor characterization and
                      quantitative assessment, which were sensitive to changes
                      after therapeutic interventions.},
      keywords     = {MRgFUS (Other) / accelerometry (Other) / quantitative
                      measurements (Other) / thalamotomy (Other) / tremor (Other)},
      cin          = {AG Wüllner / Clinical Research (Bonn) / AG Boecker},
      ddc          = {610},
      cid          = {I:(DE-2719)1011302 / I:(DE-2719)1011001 /
                      I:(DE-2719)1011202},
      pnm          = {353 - Clinical and Health Care Research (POF4-353)},
      pid          = {G:(DE-HGF)POF4-353},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:40386019},
      pmc          = {pmc:PMC12081243},
      doi          = {10.3389/fneur.2025.1594382},
      url          = {https://pub.dzne.de/record/278790},
}