% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{Rocke:278796,
      author       = {Rocke, Merle and Knochenhauer, Elena and Thams, Friederike
                      and Antonenko, Daria and Fromm, Anna Elisabeth and Jansen,
                      Nora and Aziziaram, Samaneh and Grittner, Ulrike and
                      Schmidt, Sein and Vogelgesang, Antje and Brakemeier,
                      Eva-Lotta and Flöel, Agnes},
      title        = {{N}euromodulation through brain stimulation-assisted
                      cognitive training in patients with post-chemotherapy
                      subjective cognitive impairment ({N}euromod-{PCSCI}) after
                      breast cancer: study protocol for a double-blinded
                      randomised controlled trial.},
      journal      = {BMJ open},
      volume       = {15},
      number       = {5},
      issn         = {2044-6055},
      address      = {London},
      publisher    = {BMJ Publishing Group},
      reportid     = {DZNE-2025-00632},
      pages        = {e096162},
      year         = {2025},
      abstract     = {Breast cancer is the most common form of cancer in women. A
                      considerable number of women with breast cancer who have
                      been treated with chemotherapy subsequently develop
                      neurological symptoms such as concentration and memory
                      difficulties (also known as 'chemobrain'). Currently, there
                      are no validated therapeutic approaches available to treat
                      these symptoms. Cognitive training holds the potential to
                      counteract cognitive impairment. Combining cognitive
                      training with concurrent transcranial direct current
                      stimulation (tDCS) could enhance and maintain the effects of
                      this training, potentially providing a new approach to treat
                      post-chemotherapy subjective cognitive impairment (PCSCI).
                      With this study, we aim to investigate the effects of
                      multi-session tDCS over the left dorsolateral prefrontal
                      cortex in combination with cognitive training on cognition
                      and quality of life in women with PCSCI.The Neuromod-PCSCI
                      trial is a monocentric, randomised, double-blind,
                      placebo-controlled study. Fifty-two women with PCSCI after
                      breast cancer therapy will receive a 3-week tDCS-assisted
                      cognitive training with anodal tDCS over the left
                      dorsolateral prefrontal cortex (target intervention),
                      compared with cognitive training plus sham tDCS (control
                      intervention). Cognitive training will consist of a letter
                      updating task. Primary outcome will be the performance in an
                      untrained task (n-back task) after training. In addition,
                      feasibility, safety and tolerability, as well as quality of
                      life and performance in additional untrained tasks will be
                      investigated. A follow-up visit will be performed 1 month
                      after intervention to assess possible long-term effects. In
                      an exploratory approach, structural and functional MRI will
                      be acquired before the intervention and at post-intervention
                      to identify possible neural predictors for successful
                      intervention.Ethical approval was granted by the ethics
                      committee of the University Medicine Greifswald (BB236/20).
                      Results will be available through publications in
                      peer-reviewed journals and presentations at national and
                      international conferences.ClinicalTrials.gov; NCT04817566,
                      registered on 26 March 2021.},
      keywords     = {Humans / Breast Neoplasms: drug therapy / Female /
                      Transcranial Direct Current Stimulation: methods /
                      Double-Blind Method / Quality of Life / Randomized
                      Controlled Trials as Topic / Cognitive Behavioral Therapy:
                      methods / Chemotherapy-Related Cognitive Impairment: therapy
                      / Chemotherapy-Related Cognitive Impairment: etiology /
                      Cognitive Dysfunction: therapy / Cognitive Dysfunction:
                      chemically induced / Middle Aged / Adult / Dorsolateral
                      Prefrontal Cortex / Prefrontal Cortex / Cognition /
                      Antineoplastic Agents: adverse effects / Cognitive Training
                      / CHEMOTHERAPY (Other) / Cognition (Other) / Quality of Life
                      (Other) / Antineoplastic Agents (NLM Chemicals)},
      cin          = {AG Flöel},
      ddc          = {610},
      cid          = {I:(DE-2719)5000081},
      pnm          = {353 - Clinical and Health Care Research (POF4-353)},
      pid          = {G:(DE-HGF)POF4-353},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:40398955},
      doi          = {10.1136/bmjopen-2024-096162},
      url          = {https://pub.dzne.de/record/278796},
}