% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{Temba:278797,
      author       = {Temba, Godfrey S and Pecht, Tal and Kullaya, Vesla I and
                      Vadaq, Nadira and Mosha, Mary V and Ulas, Thomas and
                      Kanungo, Sneha and van Emst, Liesbeth and Bonaguro, Lorenzo
                      and Schulte-Schrepping, Jonas and Mafuru, Elias and
                      Lionetti, Paolo and Mhlanga, Musa M and van der Ven, Andre J
                      and Cavalieri, Duccio and Joosten, Leo A B and Kavishe,
                      Reginald A and Mmbaga, Blandina T and Schultze, Joachim L
                      and Netea, Mihai G and de Mast, Quirijn},
      title        = {{I}mmune and metabolic effects of {A}frican heritage diets
                      versus {W}estern diets in men: a randomized controlled
                      trial.},
      journal      = {Nature medicine},
      volume       = {31},
      number       = {5},
      issn         = {1078-8956},
      address      = {[New York, NY]},
      publisher    = {Springer Nature},
      reportid     = {DZNE-2025-00633},
      pages        = {1698 - 1711},
      year         = {2025},
      abstract     = {African heritage diets are increasingly being replaced by
                      Western-style dietary patterns because of urbanization,
                      economic development, increased access to processed foods,
                      globalization and changing social norms. The health
                      consequences of this nutrition transition are not well
                      understood. We conducted a randomized controlled trial in
                      the Kilimanjaro region in Northern Tanzania to investigate
                      the immune and metabolic effects of switching between
                      Kilimanjaro heritage-style and Western-style diets for 2
                      weeks and consuming a traditional fermented banana beverage
                      ('Mbege') for 1 week. Seventy-seven young and healthy
                      volunteers assigned male at birth, some living in urban
                      areas and some living in rural areas, were recruited in the
                      trial. Primary outcomes were changes in the immune and
                      metabolic profile before and after the intervention and at
                      the 4-week follow-up. The switch from heritage-style to
                      Western-style diet affected different metabolic pathways
                      associated with noncommunicable diseases and promoted a
                      pro-inflammatory state with impaired whole-blood cytokine
                      responses to microbial stimulation. In contrast, the switch
                      from Western-style to heritage-style diet or consuming the
                      fermented beverage had a largely anti-inflammatory effect.
                      Some of the observed changes in the immune and metabolic
                      profiles persisted at the follow-up, suggesting a sustained
                      impact from the short-term intervention. These findings show
                      the metabolic and immune effects of dietary transitions and
                      the consumption of fermented beverages, underscoring the
                      importance of preserving indigenous dietary practices to
                      mitigate noncommunicable disease risk factors in sub-Saharan
                      Africa. ISRCTN trial registration: ISRCTN15619939 .},
      keywords     = {Humans / Male / Tanzania / Adult / Diet, Western: adverse
                      effects / Young Adult / Diet / Musa / Adolescent /
                      Cytokines: blood / Cytokines (NLM Chemicals)},
      cin          = {AG Schultze / PRECISE / AG Bonaguro},
      ddc          = {610},
      cid          = {I:(DE-2719)1013038 / I:(DE-2719)1013031 /
                      I:(DE-2719)1016005},
      pnm          = {354 - Disease Prevention and Healthy Aging (POF4-354) / 352
                      - Disease Mechanisms (POF4-352)},
      pid          = {G:(DE-HGF)POF4-354 / G:(DE-HGF)POF4-352},
      experiment   = {EXP:(DE-2719)PRECISE-20190321},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:40181181},
      pmc          = {pmc:PMC12092257},
      doi          = {10.1038/s41591-025-03602-0},
      url          = {https://pub.dzne.de/record/278797},
}